Anti-Arginase Nutrient Composition for L-Arginine and Nitric Oxide
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Solution Overview
Problem
Elevated arginase activity leads to decreased levels of L-arginine and nitric oxide, contributing to aging and various age-related diseases by causing oxidative stress, inflammation, and cellular damage.
Innovation Solution
A dietary supplement formulation combining amino acids, vitamins, mineral co-factors, antioxidants, and phytonutrients from herbal sources to inhibit arginase activity and enhance circulating L-arginine and nitric oxide levels.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If arginase activity is elevated, then L-arginine and nitric oxide levels decrease, but this contributes to aging and age-related diseases
Solution Approach 1:
The patent identifies arginase activity as a harmful factor that converts L-arginine to urea, thereby reducing nitric oxide production and contributing to aging. The invention applies the 'blessing in disguise' principle by using natural inhibitors (such as L-lysine, L-citrulline, and botanical compounds) to convert this harmful enzymatic activity into a beneficial outcome: increasing bioavailable L-arginine and nitric oxide levels while reducing oxidative stress and inflammation.
2Quantity of substance
If natural inhibitors are used to inhibit arginase, then L-arginine and nitric oxide levels increase, but the formulation complexity increases
Solution Approach 1:
The patent applies the 'merging' principle by combining multiple natural inhibitors into a single dietary supplement formulation. This includes amino acid inhibitors (L-lysine, L-citrulline, beta-alanine) and botanical inhibitors (blueberry extract, curcumin, grape seed extract, acerola fruit, noni fruit). By merging these components into one complementary product, the patent simplifies the user experience while maintaining the synergistic effect of multiple inhibitors working together to maximize arginase inhibition and nitric oxide production.
Solution Approach 2:
The invention uses a composite approach by formulating a dietary supplement that integrates multiple active ingredients from different sources (amino acids and botanical compounds). This composite formulation leverages the synergistic effects of various natural inhibitors to achieve potent arginase inhibition, thereby increasing bioavailable L-arginine and nitric oxide levels while managing formulation complexity through integrated product design.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The formulation effectively inhibits arginase, increasing bioavailable L-arginine and nitric oxide, thereby reducing oxidative stress, inflammation, and promoting health benefits such as improved vascular function, immune system function, and neuroprotection.
Implementation Method 1
inhibit arginase activity and enhance circulating L-arginine and nitric oxide levels
Implementation Method 2
reducing oxidative stress, inflammation
Data Source
AI summary
The present invention relates to a formulation providing health promoting and anti-aging benefits that may include amino acids, vitamins, mineral co-factors, antioxidants, carotenoids, and phytonutrients from herbal sources, plant products or their derivatives. When combined, these ingredients provide increased and unexpected synergistic effects that that inhibit arginase activity and enhance circulating L-arginine and nitric oxide levels.