Anti-Inflammatory Polypeptides for Cellular Senescence Modulation

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Solution Overview

Problem

Cellular senescence contributes to a positive feedback cycle that accelerates aging and various diseases, and existing treatments are inadequate in modulating key biomarkers associated with inflammation and cellular pathways.

Innovation Solution

Compositions and methods utilizing isolated, synthetic, or recombinant polypeptides with specific amino acid sequences, such as LKGI, WLKGI, or LKGIL, to modulate biomarkers involved in pathways like FoxO signaling, cellular senescence, and inflammation, thereby promoting health and reducing senescence-related conditions.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional treatments are used to address cellular senescence, then some inflammatory markers may be reduced, but key biomarkers associated with inflammation and cellular pathways remain inadequately modulated

Engineering Contradiction:

Improveefficacy in modulating biomarkersVSAvoidability to modulate multiple pathways

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The invention uses segmented peptides (LKGI, WLKGI, LKGIL) that specifically target and modulate different aspects of cellular senescence pathways, including FoxO signaling, NF-κB pathway, and inflammatory markers, thereby achieving comprehensive biomarker modulation through multiple specialized peptide agents

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The peptides disclosed in the patent exhibit multi-functional properties by simultaneously affecting multiple cellular pathways and biomarkers. For example, these peptides can modulate FoxO signaling, reduce inflammatory cytokines, and affect cell cycle regulation, making them versatile tools for addressing various aspects of cellular senescence

Inventive Principle:

Principle #6Universality (Multi-functionality)

2Stability of the object's composition

If cellular senescence is allowed to accumulate, then natural aging process occurs, but it actively contributes to further senescence induction in a positive feedback cycle accelerating disease progression

Engineering Contradiction:

Improvecellular senescence accumulationVSAvoidinflammation and disease progression

Core Design Contradiction:

Stability of the object's compositionVSObject-generated harmful factors

Solution Approach 1:

The invention applies preliminary anti-action by using peptides to preemptively counteract the positive feedback cycle of cellular senescence before it leads to significant disease progression. The peptides intervene in the senescence pathway early, preventing the amplification of harmful inflammatory signals and disease-associated changes

Inventive Principle:

Principle #9Preliminary anti-action

Solution Approach 2:

The invention converts the harmful effects of accumulated senescent cells into beneficial outcomes by using the peptides to trigger beneficial cellular responses. The peptides transform the senescence-associated inflammatory signaling into protective effects by modulating key pathways to reduce chronic inflammation and promote healthy cellular aging

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Data Source

PatentUS20250352608A1Polypeptides having Anti-inflammatory effects and uses thereof

Publication Date: 2025.11.20 ONESKIN INC

AI summary

Polypeptides which can provide a senotherapeutic and anti-inflammatory effect are provided herein. The polypeptides can be formulated for topical application or a systemic application and can be applied topically or delivered systemically to a subject to provide a senotherapeutic effect and/or anti-inflammatory effect in the subject or in the cells of the subject.