Anti-TIM-3 Antibody Binding Specificity
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Solution Overview
Problem
Current therapies lack effective molecules that specifically regulate TIM-3 function and the function of TIM-3 expressing cells, which are crucial for immune responses and are implicated in various diseases including cancer and autoimmune disorders.
Innovation Solution
Development of a pharmaceutical composition comprising an isolated antibody molecule that binds to human T-cell immunoglobulin domain and mucin domain 3 (TIM-3) with high affinity and specificity, capable of modulating TIM-3 activity, alone or in combination with other therapeutic agents, to treat cancer and immune disorders.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current therapies are used, then treatment is provided for cancer and immune disorders, but effective molecules that specifically regulate TIM-3 function are lacking
Solution Approach 1:
The patent applies parameter changes by developing antibody molecules with specific binding characteristics to TIM-3. The antibodies are designed to bind to TIM-3 with defined affinity parameters, enabling specific regulation of TIM-3 function. This allows the therapy to specifically target TIM-3 expressing cells while maintaining effective treatment outcomes, resolving the contradiction between general effectiveness and specific regulatory capability.
2Productivity
If TIM-3 function is regulated to enhance immune responses, then cancer and immune disorders can be treated, but the mechanism requires high affinity and specificity binding
Solution Approach 1:
The patent applies local quality by designing antibodies with specific structural characteristics in their binding regions. The variable regions of the antibodies are engineered to have precise local properties that enable high affinity and specificity binding to TIM-3. This localized precision in the binding regions allows the antibodies to effectively regulate TIM-3 function and enhance immune responses without requiring complex modifications throughout the entire molecule.
Data Source
Figure 1A~1B
Figure 2A~2C
Figure 2D~2E
AI summary
Antibody molecules that specifically bind to TIM-3 are disclosed. The anti-TIM-3 antibody molecules can be used to treat, prevent and/or diagnose immune, cancerous, or infectious conditions and/or disorders.