Antibacterial Peptides from Fungal Date Pit Degradation
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Solution Overview
Problem
The use of conventional antibiotics in animal feed to promote growth and prevent bacterial infections leads to antibiotic resistance and residual antibiotics in meat products, prompting a need for alternative solutions that are effective and safe for human consumption.
Innovation Solution
An antibacterial peptide derived from degraded date pits, specifically degraded by Trichoderma reesei through solid state degradation, is administered to animals to treat and prevent bacterial infections, reducing the reliance on conventional antibiotics and promoting growth.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional antibiotics are administered to animals to promote weight gain and prevent bacterial infections, then growth promotion and infection prevention are achieved, but antibiotic resistance develops and residual antibiotics remain in meat products
Solution Approach 1:
The patent extracts and isolates specific antibacterial peptides (such as oryzacins and other cyclic peptides) from natural sources like rice bran and other agricultural byproducts. This extraction process separates the beneficial antibacterial components from the rest of the material, creating a concentrated peptide preparation that can be administered to animals without the harmful side effects of conventional antibiotics
Solution Approach 2:
The patent utilizes inexpensive agricultural byproducts such as rice bran, date pits, and other plant materials as sources of antibacterial peptides. These readily available, low-cost materials are processed to extract active peptides, providing an economical alternative to expensive conventional antibiotics while eliminating the problem of antibiotic resistance
2Productivity
If antibiotics are used in animal feed, then bacterial infections are controlled and growth is promoted, but feed costs increase and safety concerns arise for human consumption
Solution Approach 1:
The patent converts agricultural waste materials that would normally be discarded into valuable sources of antibacterial peptides. By processing rice bran, date pits, and other plant byproducts through fermentation and extraction processes, the patent transforms worthless or low-value waste into high-value antibacterial preparations that promote animal health and growth without the harmful effects of conventional antibiotics
Solution Approach 2:
The patent employs fermentation intermediaries such as lactic acid bacteria, yeast, and other microorganisms to process plant materials and generate antibacterial peptides. These microbial intermediaries convert complex plant materials into bioactive peptide compounds that can be easily administered to animals and are safely metabolized or eliminated, leaving no harmful residues in meat products
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The antibacterial peptide effectively reduces microbial loads and prevents bacterial infections in animals, achieving similar weight gain and feed conversion ratios as antibiotic-supplemented feeds without the residual antibiotic concerns, making it a safe alternative for human consumption.
Implementation Method 1
an antibacterial peptide derived from degraded date pits, specifically degraded by Trichoderma reesei through solid state degradation
Data Source
AI summary
A method of treating or preventing a bacterial infection in an animal comprises administering to the animal an effective amount of an antibacterial peptide, the antibacterial peptide being derived from degraded date pits which are degraded by solid state degradation by a fungus, Trichoderma reesei. The antibacterial peptide has a molecular mass of less than 10 kDa and an amino acid sequence including (a) SEQ ID NO:4 or (b) SEQ ID NO:6. The bacterial infection is caused by a Gram-positive bacteria or a Gram-negative bacteria, for example, a Salmonella species, a Campylobacter species, a Shigella species, an Escherichia species, a Pseudomonas species, and a Staphylococcus species.