Non-stick Antibiotic Gel Emulsion for Bone Defect Filling
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Solution Overview
Problem
Existing compositions for preventing or eliminating infection at bone defect sites during surgical interventions tend to stick to medical gloves, complicating procedures and reducing their availability for application, and they lack suitable rheological properties to remain in place effectively.
Innovation Solution
An oil-in-water emulsion gel with specific rheological properties is developed, which exhibits low stickiness to medical gloves and cohesive properties, allowing it to be effectively applied and stay in place, comprising a pharmaceutically acceptable oil, an aqueous phase, an osmotic agent, an emulsifying agent, and a gelling polysaccharide, optionally mixed with bioactive agents.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If existing compositions are applied to prevent or eliminate infection at bone defect sites, then the local antibiotic concentration is increased, but the compositions strongly stick to the outer glove surface, complicating the procedure and causing loss of composition
Solution Approach 1:
The patent modifies the rheological parameters of the composition by adding gelling agents (carbomer, hydroxyethyl cellulose, carboxymethyl cellulose) and adjusting viscosity to optimize the balance between adhesion to bone tissue and non-adhesion to glove surfaces. The composition achieves high local concentration through controlled viscosity and gel formation while minimizing unwanted adhesion to medical gloves.
2Quantity of substance
If existing compositions are applied to prevent or eliminate infection, then the antibiotic concentration is increased locally, but the compositions lack suitable rheological properties to remain in place effectively
Solution Approach 1:
The patent adjusts rheological parameters including viscosity, gel strength, and viscoelastic properties by incorporating specific gelling agents and polymers. This enables the composition to remain in place at the bone defect site while maintaining high antibiotic concentration, achieving both localized delivery and positional stability.
Solution Approach 2:
The patent creates a composite formulation combining antibiotics with gelling agents, polymers, and excipients to achieve dual functionality: high antibiotic concentration for infection prevention and appropriate rheological properties for staying in place. The composite nature allows independent optimization of both concentration and rheological behavior.
3Reliability
If the composition is made more adhesive to stay in place, then the ability to remain at the site is improved, but the stickiness to medical gloves increases, complicating the procedure
Solution Approach 1:
The patent optimizes adhesion parameters by controlling viscosity, gel strength, and surface interaction properties through selective use of gelling agents and polymers. This creates a composition that adheres sufficiently to remain at the bone defect site while maintaining low adhesion to medical glove surfaces, ensuring ease of surgical application.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The emulsion gel effectively fills bone defects, adheres to biomaterials, and prevents inflammation and fibrous encapsulation, while minimizing loss due to glove adhesion, ensuring sustained delivery of bioactive agents and reducing re-infection risks.
Implementation Method 1
mixing a gelling polysaccharide with the oil-in-water emulsion and allowing the resulting mixture to form the pharmaceutical gel emulsion
Implementation Method 2
forming an oil-in-water emulsion by dispersing at least one pharmaceutically acceptable oil and at least one osmotic agent in the first dispersion
Implementation Method 3
at least one osmotic agent
Data Source
AI summary
A method of producing a pharmaceutical gel emulsion, wherein the emulsion is an oil-in-water gel emulsion, comprising the steps of forming an oil-in-water emulsion comprising at least one pharmaceutically acceptable oil, at least one aqueous phase, at least one osmotic agent, at least one emulsifying agent, mixing a gelling polysaccharide with the oil-in-water emulsion and allowing the resulting mixture to form the pharmaceutical gel emulsion, optionally mixing an bioactive agent into the pharmaceutical gel emulsion.