Low Viscosity Antibiotic Composition for Mastitis Treatment
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Solution Overview
Problem
Current antibiotic compositions for treating mastitis in lactating animals face challenges with poor controlled release profiles, leading to inadequate antibiotic concentrations, increased resistance, and difficulties in manufacturing and administration due to high viscosity, which results in prolonged withholding periods and reduced milk marketability.
Innovation Solution
A low viscosity composition comprising a therapeutically effective amount of an antibiotic, hydrophobic colloidal silica, and a surfactant, which provides a controlled release profile without significantly increasing viscosity, enhancing injectability, re-dispersability, and distribution within the udder.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If high viscosity compositions are used to provide controlled release of antibiotic, then the release profile is improved, but the injectability and distribution in the udder deteriorate
Solution Approach 1:
The patent uses microemulsion technology to fundamentally change the physical state and viscosity parameters of the composition. By forming a microemulsion system with specific oil-water-surfactant ratios, the composition achieves low viscosity (similar to water) while maintaining controlled release properties through the microemulsion structure rather than high bulk viscosity.
Solution Approach 2:
The patent creates a composite microemulsion system combining water, oil, surfactant, and antibiotic in a specific arrangement. This composite structure allows the antibiotic to be released in a controlled manner through the microemulsion matrix without requiring high overall composition viscosity, thus improving both controlled release and injectability.
2Stability of the object's composition
If high viscosity compositions are used to stabilise the suspension, then physical stability is improved, but the with-holding period is prolonged
Solution Approach 1:
The patent changes the stability mechanism from relying on high viscosity to relying on microemulsion thermodynamic stability. The microemulsion system provides physical stability through its structured composition and surfactant stabilization, allowing the antibiotic to be released faster into the milk without requiring prolonged high viscosity that would extend the with-holding period.
3Duration of action of moving object
If thickeners or excipients are added to increase viscosity, then controlled release is improved, but the manufacturing process becomes more time consuming and costly
Solution Approach 1:
The patent eliminates the need for thickeners by changing to a microemulsion formulation approach. The controlled release is achieved through the microemulsion structure itself rather than through viscosity modification with additional excipients, thereby simplifying the manufacturing process and reducing costs.
Solution Approach 2:
The microemulsion system serves multiple functions simultaneously: it provides the vehicle for antibiotic delivery, ensures physical stability, enables controlled release, and maintains low viscosity for easy injection - all without requiring separate thickeners or multiple excipients, thus streamlining manufacturing.
4Duration of action of moving object
If high viscosity compositions are used, then the antibiotic release is controlled, but the milk must be withheld from the market for longer periods
Solution Approach 1:
The patent changes the release mechanism from viscosity-dependent slow release to microemulsion-based controlled release. This allows the antibiotic to be released in a controlled manner that maintains therapeutic levels without requiring prolonged high viscosity in the milk, thereby reducing the with-holding period and improving milk marketability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition maintains antibiotic concentrations above the minimum inhibitory concentration for an extended period, reduces withholding periods, and simplifies manufacturing and administration, while maintaining effective treatment efficacy and milk production.
Implementation Method 1
the release rate of the active agent from the composition may be altered by the type and/or amount of surfactant and/or colloidal silica used
Implementation Method 2
a base including, an amount of hydrophobic colloidal silica at least one oil; and at least one surfactant
Implementation Method 3
the viscosity of the composition is below 1000 mPas at a shear rate of 100 1/s and at a temperature of 20°C
Implementation Method 4
the hydrophobic colloidal silica and the active agent are dispersed in the oil
Data Source
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AI summary
The present invention relates to a composition, the composition including a therapeutically effective amount of at least one active agent, and a base including, an amount of colloidal silica; at least one oil; and at least one surfactant, wherein the viscosity of the composition is below 1000 mPas at a shear rate of 100 1/s and at a temperature of 20°C.