Anti-Fibrotic Polymer Implants for Local Immune Modulation
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Solution Overview
Problem
Existing implanted devices face challenges in modulating the immune response of the recipient, affecting their functionality and efficacy.
Innovation Solution
Development of compounds of Formula (I) and polymers modified with compounds of Formula (II), which can be incorporated into implantable elements to modulate the immune response, either upregulating or downregulating it as needed.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If implantable devices are introduced into the body, then therapeutic function is provided, but immune response causes fibrosis and device failure
Solution Approach 1:
The patent uses compounds of Formula (I) and modified polymers as intermediary substances between the implantable device and the host immune system. These compounds modulate the immune response by interacting with immune cells, preventing fibrosis formation, and maintaining device functionality without direct contact between the device and harmful immune components.
Solution Approach 2:
The patent converts the harmful immune response into a beneficial effect by using immunomodulatory compounds that redirect immune cell activity. Instead of allowing fibrosis-causing immune responses, the compounds promote anti-fibrotic effects and enhance device acceptance by the host tissue.
2Duration of action of stationary object
If immune response is suppressed to protect device, then device longevity increases, but therapeutic efficacy may be reduced
Solution Approach 1:
The patent modifies the immune response parameters selectively rather than globally suppressing immunity. The compounds of Formula (I) change specific immune parameters such as fibrosis markers while maintaining other immune functions necessary for therapeutic efficacy, achieving localized immunomodulation.
Solution Approach 2:
The patent applies immunomodulation locally at the device-tissue interface rather than systemically throughout the body. The modified polymers and compounds are positioned at the implant site to modulate immune responses specifically where the device contacts tissue, preserving systemic immune function while protecting the device.
Data Source
AI summary
Described herein are compounds of Formula (I), modified polymers and implantable elements comprising compounds of Formula (II), as well as compositions and methods of use thereof. In particular, the compounds, modified polymers, implantable elements and related compositions may be used in methods for the prevention and treatment of a disease, disorder or condition in a subject.