Antifungal Composite with Modified Beta-Cyclodextrin for Resin Surfaces

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Solution Overview

Problem

Existing antifungal composites for food products face challenges in enhancing antifungal effects due to the shielding of antifungal agent release when mixed with resin materials, leading to reduced surface contact and efficacy.

Innovation Solution

An antifungal composite comprising an antifungal agent clad in β-cyclodextrin surface-modified with a long carbon chain compound, which is incorporated into resin sheets to enhance the antifungal effect through sustained release and increased surface contact, utilizing a chemical or physically calendaring process.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Ease of manufacture

If the antifungal composite is mixed with resin material, then the composite can be incorporated into packaging materials, but the release of antifungal agent is shielded and surface contact area is reduced

Engineering Contradiction:
Improveincorporation into packaging materialVSAvoidantifungal effect
Core Design Contradiction:
Ease of manufactureVSReliability

Solution Approach 1:

The patent applies local quality by surface-modifying β-cyclodextrin with long carbon chain compounds to create amphiphilic characteristics. This modification concentrates the antifungal agent release at the surface of the resin material rather than throughout the bulk, ensuring that the antifungal effect occurs precisely where it is needed (at the surface contacting food or environment) while maintaining ease of manufacture through uniform mixing during the calendaring process.

Inventive Principle:
Principle #3Local quality

Solution Approach 2:

The patent creates a composite system combining β-cyclodextrin, long carbon chain compounds, and antifungal agents. The β-cyclodextrin forms inclusion complexes with the antifungal agent, while the long carbon chain modification provides amphiphilic properties that enable surface retention on hydrophobic resin materials. This composite structure resolves the contradiction by maintaining both manufacturability and enhanced antifungal efficacy.

Inventive Principle:
Principle #40Composite materials

2Quantity of substance

If a small amount of antifungal agent is used, then the composite is more efficient, but the antifungal effect may be insufficient without adequate surface contact

Engineering Contradiction:
Improveamount of antifungal agentVSAvoidantifungal effect
Core Design Contradiction:
Quantity of substanceVSReliability

Solution Approach 1:

The patent changes the physical and chemical parameters of β-cyclodextrin by surface-modifying it with long carbon chain compounds. This modification alters the surface properties to be more lipophilic, enabling better adhesion to hydrophobic resin surfaces. As a result, even small amounts of antifungal agent loaded in the modified β-cyclodextrin can achieve sufficient surface concentration and contact area to maintain reliable antifungal effects.

Inventive Principle:
Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The antifungal composite achieves an excellent antifungal effect with a small amount of antifungal agent by adjusting the lipophilic and hydrophilic characters, ensuring effective inhibition of harmful fungi and increased surface concentration on resin materials.

Implementation Method 1

β-cyclodextrin contains a lipophilic central cavity and a hydrophilic outer surface... The central cavity has hydrogen atoms and ethereal oxygens of the glucose residues, which gives it a lipophilic or nonpolar character. β-cyclodextrin can form composites with various compounds, e.g. antifungal agents.

Methodology Applied
Scientific EffectInclusion complex formation: Solvation

Implementation Method 2

β-cyclodextrin surface-modified with a long carbon chain compound... adjusting the difference of the lipophilic and hydrophilic characters between the antifungal composite and the resin materials... increase the concentration of the antifungal composite on the surface of the resin materials

Methodology Applied
Scientific EffectSurface modification with long carbon chain compound: Surfactant

Implementation Method 3

The antifungal effect can be produced by sustained release and migration of the antifungal agent from the composite

Methodology Applied
Scientific EffectSustained release: Diffusion

Data Source

PatentUS9505851B2Antifungal composite and method for manufacturing the same
Publication Date: 2016.11.29 SU
  • US9505851B2 patent drawing
  • US9505851B2 patent drawing
  • US9505851B2 patent drawing

AI summary

The invention provides an antifungal composite comprising an antifungal agent and β-cyclodextrin surface-modified with a long carbon chain compound, wherein the antifungal agent is clad in β-cyclodextrin surface-modified with a long carbon chain compound as a carrier, and thus a use of inhibiting harmful fungi can be provided by sustained release of the antifungal agent from the composite. The antifungal composite may be retained on the surface of the resin materials to increase the concentration of the antifungal composite on the surface of the resin materials by adjusting the difference of the lipophilic and hydrophilic characters between the antifungal composite and the resin materials, and thus an antifungal effect can be increased. The invention also relates to a method for manufacturing an antifungal composite.