Antifungal Composition Synergy Polyene Triazole

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Solution Overview

Problem

Current antimicrobial compositions, particularly fungicides, face challenges such as resistance development, side effects on plants, and limited effectiveness against certain fungal diseases like Oomycete diseases, leading to significant crop losses and food spoilage.

Innovation Solution

A synergistic antimicrobial composition combining a polyene antifungal compound with at least one triazole fungicide, which exhibits enhanced antifungal activity beyond the additive effects of individual components, effectively controlling fungal growth on plants and crops.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If triazole fungicides are used to control fungal diseases, then antifungal effectiveness is improved, but resistance development occurs and plant side effects increase

Engineering Contradiction:

Improveantifungal effectivenessVSAvoidplant side effects and resistance

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent combines polyene antifungal compounds with triazole fungicides or benzimidazole fungicides to create a synergistic mixture. This merging of different antifungal mechanisms achieves enhanced effectiveness while reducing resistance development and plant side effects compared to using triazoles alone.

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The invention creates a composite antifungal composition by combining polyene compounds with triazole or benzimidazole fungicides. This composite approach leverages the complementary modes of action of different antifungal classes to overcome the limitations of single-agent therapy.

Inventive Principle:

Principle #40Composite materials

2Ease of operation

If single antifungal compounds are used, then application simplicity is maintained, but resistance development and reduced effectiveness occur

Engineering Contradiction:

Improveapplication simplicityVSAvoidantifungal effectiveness

Core Design Contradiction:

Ease of operationVSReliability

Solution Approach 1:

The patent merges multiple antifungal compounds into a single combined composition that can be applied together. This maintains the simplicity of single-application methods while achieving the reliability benefits of multi-component antifungal strategies through synergistic interactions.

Inventive Principle:

Principle #5Merging (Combining)

Data Source

PatentUS8946121B2Antifungal compositions

Publication Date: 2015.02.03 DSM IP ASSETS BV

AI summary

The present invention relates to new antifungal compositions and their use in the treatment of agricultural products.