Antifungal Composition Synergy Polyene Strobilurin
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Solution Overview
Problem
Current fungicides, such as strobilurins, face issues with resistance development and toxicity, leading to ineffective control of fungal spoilage in crops, while natural preservatives like natamycin lack synergistic combinations for enhanced antifungal activity.
Innovation Solution
A synergistic antimicrobial composition combining polyene antifungal compounds like natamycin with strobilurin fungicides, such as azoxystrobin and trifloxystrobin, to create a formulation that exceeds the additive effects of individual compounds, providing enhanced antifungal activity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If strobilurin fungicides are used to control fungal diseases, then antifungal activity is improved, but resistance development and toxicity increase
Solution Approach 1:
The patent combines polyene antifungal compounds (natamycin, nystatin) with strobilurin fungicides in a single composition. This merging creates a synergistic effect where the combination achieves enhanced antifungal activity while reducing the harmful effects of resistance development and toxicity associated with using strobilurins alone.
Solution Approach 2:
The invention creates a composite antifungal composition that integrates two different classes of antifungal agents (polyenes and strobilurins) with distinct modes of action. This composite approach allows the formulation to leverage the strengths of each component while mitigating their individual weaknesses, particularly resistance development and toxicity.
2Object-affected harmful factors
If polyene antifungal compounds like natamycin are used, then safety and environmental friendliness are improved, but antifungal activity is insufficient when used alone
Solution Approach 1:
The patent merges polyene antifungal compounds (which are safe and environmentally friendly) with strobilurin fungicides (which provide potent antifungal activity) in a synergistic combination. This allows the composition to achieve high antifungal effectiveness while maintaining the safety and environmental benefits of the polyene component.
Solution Approach 2:
The invention changes the concentration parameters of the individual components to optimize synergistic effects. By carefully controlling the ratios of polyene to strobilurin in the composition, the patent achieves enhanced antifungal activity that exceeds the simple sum of individual effects, while maintaining safety profiles.
3Ease of operation
If single fungicide compounds are used, then application simplicity is improved, but effectiveness decreases due to resistance
Solution Approach 1:
The patent combines multiple antifungal compounds with different modes of action into a single integrated composition. This allows farmers to apply one product that delivers the combined benefits of multiple agents, maintaining application simplicity while overcoming resistance through the synergistic interaction of the different compounds.
Data Source
AI summary
The present invention relates to new antifungal compositions and their use in the treatment of agricultural products.