Antigen Binding Molecules Targeting Murine TCR Alpha Chain
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Solution Overview
Problem
Current antigen binding molecules, such as antibodies, lack specificity and efficiency in binding to the alpha chain of the constant region of the murine T cell receptor (TCR) or its fragments, limiting their utility in immunotherapy and biosensor applications.
Innovation Solution
Development of isolated antigen binding molecules, including antibodies and their fragments, that specifically bind to the alpha chain of the murine TCR or its fragments, with humanized forms and specific sequences for enhanced binding affinity, and methods for detecting and quantifying these molecules in samples.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional antigen binding molecules are used, then they can bind to various antigens, but they lack specificity and efficiency in binding to the alpha chain of the murine TCR
Solution Approach 1:
The patent develops antigen binding molecules with specifically optimized binding sites that target only the alpha chain of the murine TCR constant region. The molecules are engineered with particular affinity for this specific epitope while maintaining reduced cross-reactivity with other TCR chains or unrelated antigens, achieving localized high-quality binding specificity.
2Reliability
If antigen binding molecules are designed for high specificity to murine TCR alpha chain, then binding efficiency improves, but development complexity increases
Solution Approach 1:
The patent extracts and isolates the specific binding characteristics required for murine TCR alpha chain recognition. By focusing on the essential epitope features and creating simplified molecular structures that target only this specific antigen region, the design process becomes more systematic and less complex while achieving high binding affinity.
3Measurement precision
If conventional antibodies are used for detection, then they can detect various targets, but they lack the precision needed for accurate quantification of murine TCR alpha chain
Solution Approach 1:
The patent optimizes key parameters of the antigen binding molecules including affinity constants, epitope specificity, and molecular structure characteristics to achieve precise detection of murine TCR alpha chain. These parameter optimizations enable accurate quantification while maintaining feasible production methods through standardized molecular design approaches.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The described antigen binding molecules demonstrate high specificity and binding affinity to the alpha chain of the murine TCR, enabling effective detection and quantification, and potential applications in immunotherapy and biosensor technologies.
Implementation Method 1
antigen binding molecules, including antibodies, that specifically bind a polypeptide comprising the alpha chain of the constant region of the murine T cell receptor (TCR)
Data Source
AI summary
Isolated antigen binding molecules that specifically bind to a polypeptide comprising the alpha chain of the constant region of a T cell receptor (TCR) are provided. The antigen binding molecules may be used in the methods provided herein.