Antigenic Compositions for Cross-Protective Immunity
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Solution Overview
Problem
Current immunological therapies for microbial infections often fail to effectively treat or prevent pathologies caused by heterologous microbial organisms, as they typically target specific serovars and lack cross-protective immunity against diverse pathogens.
Innovation Solution
The use of antigenic compositions derived from microbial pathogens, including whole killed bacterial, viral, or fungal species, to elicit an immune response against heterologous infections by targeting specific tissues or organs, even if the pathogen is not the exact strain used in the composition, leveraging cross-reactivity for protective immunity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If vaccines are formulated to target specific serovars, then specific adaptive immune response is improved, but cross-protective immunity against heterologous pathogens deteriorates
Solution Approach 1:
The patent applies universality by designing a vaccine composition that elicits a broad innate immune response capable of recognizing and responding to multiple different microbial pathogens and serovars. The composition includes microbial cells or components that stimulate pattern recognition receptors to produce cytokines and activate immune cells, providing cross-protective immunity against heterologous pathogens while maintaining protection against the target pathogen.
2Reliability
If conventional immunological therapies are used, then treatment of specific pathogen is improved, but effectiveness against heterologous microbial organisms deteriorates
Solution Approach 1:
The patent uses cytokines as intermediaries in the immune response. The vaccine composition stimulates the production of cytokines that act as mediators to activate and coordinate the immune system's response to multiple different pathogens. These cytokines serve as universal signals that bridge the gap between pathogen recognition and immune activation, enabling cross-protective immunity.
3Adaptability or versatility
If multivalent vaccines targeting multiple serovars are used, then specific adaptive response to multiple pathogens is improved, but complexity of vaccine formulation deteriorates
Solution Approach 1:
The patent extracts and utilizes conserved microbial components and pattern recognition receptors that are common across different pathogens and serovars. Instead of incorporating multiple specific antigens from different serovars, the composition focuses on extracting and stimulating the universal immune recognition mechanisms that detect common microbial patterns, thereby simplifying the formulation while maintaining broad coverage.
Data Source
AI summary
The invention provides methods of modulating an immune system in a vertebrate host for the therapeutic or prophylactic treatment of infection by a first microbial pathogen in a target tissue, comprising administration at an administration site of an effective amount of an antigenic formulation comprising antigenic determinants specific for a second heterologous microbial pathogen.