Antimicrobial And Antithrombotic Articles With Adhesion-Reducing Copolymers
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Solution Overview
Problem
Existing artificial materials suffer from adhesion of proteins, blood components, cells, or bacteria, leading to poor performance and harmful biological reactions.
Innovation Solution
A copolymer containing a vinyl alcohol unit and a vinyl monomer unit with a side chain, with a specific molar ratio, is used to reduce adhesion, exhibiting low protein, cell, and bacterial adhesion.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If conventional artificial materials are used, then manufacturing is simple and cost-effective, but adhesion of proteins, blood components, cells, or bacteria occurs leading to poor performance and harmful biological reactions
Solution Approach 1:
The patent applies composite materials by creating a copolymer that combines vinyl alcohol units with vinyl monomer units containing specific side chains (carboxyl, hydroxyl, or amino groups). This composite polymer structure integrates multiple functional groups within a single material system, achieving reduced adhesion of proteins, blood components, cells, and bacteria while maintaining manufacturability. The specific molar ratio range (60/40)-(90/10) optimizes the balance between adhesion prevention and material properties.
2Object-affected harmful factors
If fluorine-containing polymer coating is applied to prevent protein adsorption, then protein adhesion is reduced, but the material lacks broad-spectrum effectiveness against cells and bacteria
Solution Approach 1:
The patent applies local quality by incorporating different functional side chains (carboxyl, hydroxyl, and amino groups) at specific positions within the polymer structure. Each functional group provides localized chemical properties that interact differently with various biological components. The vinyl monomer units with these side chains are distributed throughout the polymer chain at controlled ratios, creating local regions with specific adhesion-preventing properties that collectively provide broad-spectrum effectiveness against proteins, blood components, cells, and bacteria.
Solution Approach 2:
The patent achieves universality by designing a copolymer structure where vinyl alcohol units combined with vinyl monomer units containing carboxyl, hydroxyl, or amino side chains provide multiple functions in a single material. This multi-functional copolymer simultaneously prevents adhesion of proteins, blood components, cells, and bacteria, making it universally applicable across different biomedical applications without requiring separate specialized coatings for each biological threat.
3Object-affected harmful factors
If temperature responsive polymer is used to prevent adhesion of blood components, then antithrombotic performance is achieved, but the material does not provide antimicrobial or cell culture functionality
Solution Approach 1:
The patent achieves universality by designing a copolymer structure where vinyl alcohol units combined with vinyl monomer units containing carboxyl, hydroxyl, or amino side chains provide multiple functions in a single material. This multi-functional copolymer simultaneously prevents adhesion of proteins, blood components, cells, and bacteria, making it universally applicable across different biomedical applications without requiring separate specialized coatings for each biological threat.
Data Source
AI summary
The invention provides an antimicrobial article, a cell culture article, an antithrombotic article, or a biopharmaceutical article that can reduce adhesion of proteins, blood components, cells, or bacteria. The antimicrobial article, the cell culture article, the antithrombotic article, or the biopharmaceutical article contains a copolymer that contains a polymerized unit (A) represented by -CH2-CHOH- and a polymerized unit (B) represented by -CH2-CX2-, wherein Xs are the same as or different from each other, and are each an alkyl group having a carbon number of 1 or greater, having a linear, branched, or cyclic structure, and optionally containing an oxygen atom between carbon atoms, an alkoxy group having a carbon number of 1 or greater, having a linear, branched, or cyclic structure, and optionally containing a hetero atom between carbon atoms, a siloxy group having a carbon number of 3 or greater, an ester group containing an aromatic ring or an alkyl group having a carbon number of 1 or greater and having a linear, branched, or cyclic structure, or H, excluding those in which both Xs are H.