Synergistic Antimicrobial Combinations for Personal Care
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing personal care products face challenges in maintaining antimicrobial efficacy while minimizing the concentration of antimicrobial agents to avoid side effects such as skin irritation and allergic reactions.
Innovation Solution
The use of a mixture comprising 3-hydroxypropyl caprylate and 3-hydroxypropyl undecylenate, in combination with other antimicrobial agents like piroctone olamine, climbazole, and zinc pyrithione, to enhance antimicrobial activity while reducing the overall concentration of these agents.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If the concentration of antimicrobial agents is increased to improve antimicrobial efficacy, then protection against pathogenic microorganisms is enhanced, but skin irritation and allergic reactions increase
Solution Approach 1:
The patent changes the chemical parameters by introducing novel compounds (3-hydroxypropyl caprylate and 3-hydroxypropyl undecylenate) with modified molecular structures that alter the antimicrobial mechanism, achieving effective protection at lower concentrations thereby reducing skin irritation and allergic reactions
Solution Approach 2:
The patent creates composite antimicrobial systems by combining multiple agents (3-hydroxypropyl caprylate, 3-hydroxypropyl undecylenate, and other antimicrobial compounds) that work synergistically to enhance efficacy while allowing each component to be used at reduced concentrations, minimizing harmful side effects
2Object-affected harmful factors
If the concentration of antimicrobial agents is reduced to minimize side effects, then skin safety is improved, but antimicrobial efficacy decreases
Solution Approach 1:
The patent modifies the concentration parameter by achieving effective antimicrobial protection at lower concentrations (0.01-5% w/w) through the use of novel compounds with enhanced activity, thereby reducing skin irritation while maintaining efficacy
Solution Approach 2:
The patent employs composite formulations combining multiple antimicrobial agents at optimized low concentrations that work synergistically to maintain high efficacy while minimizing total active ingredient content and associated side effects
3Reliability
If common antimicrobial agents are used to ensure product safety, then protection against microorganisms is achieved, but undesirable side effects occur
Solution Approach 1:
The patent changes the chemical composition parameters by replacing common antimicrobial agents with novel compounds (3-hydroxypropyl caprylate and 3-hydroxypropyl undecylenate) that have different mechanisms of action, achieving product safety without the undesirable side effects associated with traditional agents
Solution Approach 2:
The patent introduces new antimicrobial compounds that can be used at lower concentrations and potentially replaced more frequently or in combination, achieving sustained protection with reduced individual agent exposure and minimized cumulative side effects
Data Source
AI summary
The present invention primarily relates to the use of use of one or more compound(s) selected from the group as defined herein in constituent (i) to improve the antimicrobial effect of one or more compound(s) selected from the group as defined herein in constituent (ii) and/or the use of one or more compound(s) selected from the group as defined herein in constituent (ii) to improve the antimicrobial effect of one or more compound(s) selected from the group as defined herein in constituent (i). Moreover, the present invention relates to the use of a mixture comprising or consisting of constituents (i) and (ii) as defined herein for providing an antimicrobial effect, preferably to a solid or liquid personal care product or to a semi-finished product. The present invention further relates to a process for improving the antimicrobial effect of one or more compound(s) as defined in step a) and/or of one or more compound(s) as defined in step b) and a process for antimicrobial stablilisation of a personal care product or a semi-finished product as defined herein. It also relates to a mixture comprising or consisting of constituents (i) and (ii) as defined herein, preferably wherein the total amounts of constituents (i) and (ii), respectively, contained in the mixture are such that constituent (i) synergistically improves the antimicrobial effect of constituent (ii) and/or that constituent (ii) synergistically improve(s) the antimicrobial effect of constituent (i).