Antimicrobial Combinations Using Hydroxamic Acid Synergy
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Solution Overview
Problem
There is a need for antimicrobial preservation systems that provide excellent efficacy while minimizing the use of preservatives to address consumer acceptance, health concerns, regulatory restrictions, and sustainability goals in household and cosmetic formulations.
Innovation Solution
A combination of compounds of Formula (I) comprising saturated or unsaturated hydrocarbon chains, sorbitan esters, isosorbide esters, and glyceryl ethers, along with hydroxamic acids or their salts, exhibiting a synergistic effect against a broad spectrum of microorganisms, allowing for reduced preservative use and improved sustainability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If well-known preservation actives with excellent efficacy are used, then antimicrobial performance is improved, but consumer acceptance deteriorates and health concerns arise
Solution Approach 1:
The patent combines caprylic/capric acid (fatty acids) with hydroxamic acids to create a composite preservation system. This composite approach allows the use of naturally-derived fatty acids at lower concentrations while maintaining excellent antimicrobial efficacy, thereby reducing consumer concerns about synthetic preservatives while preserving reliability.
Solution Approach 2:
The invention changes the chemical parameters of the preservation system by using naturally-derived fatty acids (caprylic and capric acid) instead of conventional synthetic preservatives. This parameter change maintains antimicrobial performance while improving consumer acceptance and addressing health concerns through natural origin ingredients.
2Reliability
If higher levels of preservatives are used to ensure excellent antimicrobial performance, then reliability is improved, but resource consumption increases and sustainability deteriorates
Solution Approach 1:
The synergistic combination of caprylic/capric acid with hydroxamic acids creates a composite preservation system where the combined effect exceeds the sum of individual components. This allows achieving excellent antimicrobial performance with lower overall preservative levels, reducing resource consumption and improving sustainability.
Solution Approach 2:
The naturally-derived fatty acids (caprylic and capric acid) occur naturally in coconut and palm kernel oils, representing a renewable, sustainable resource. This self-service approach uses naturally occurring substances that can be replenished through agricultural production, reducing dependency on synthetic chemical resources.
3Duration of action of stationary object
If conventional preservatives are used to extend shelf life, then duration of action is improved, but environmental friendliness deteriorates
Solution Approach 1:
The invention changes the environmental parameters by substituting conventional synthetic preservatives with naturally-derived fatty acids and hydroxamic acids. These natural ingredients degrade more environmentally friendly, reducing harmful environmental factors while maintaining shelf life extension capabilities.
Solution Approach 2:
The patent converts potentially harmful synthetic preservatives into beneficial natural ingredients. Caprylic and capric acids, naturally occurring in coconut and palm kernel oils, provide preservation functionality while being biodegradable and environmentally friendly, thus converting a harmful necessity into a beneficial solution.
Data Source
AI summary
The present disclosure relates to a combination that includes(A) at least one compound selected fromcompounds of Formula (I)wherein R is selected from saturated hydrocarbon chains having 5 to 23 carbon atoms, unsaturated hydrocarbon chains having 5 to 23 carbon atoms, and mixtures thereof,sorbitan esters, isosorbide esters, and glyceryl ethers; and(B) at least one hydroxamic acid or a salt thereof.