Antimicrobial Medical Kit Package Matrix Vehicle

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Solution Overview

Problem

Medical devices face challenges in maintaining a sufficient antimicrobial agent content over time without adverse effects on surface properties or cytotoxicity, especially during storage and use in vivo.

Innovation Solution

A matrix type antimicrobial vehicle with a matrix layer, an antimicrobial agent-releasing layer, and a release liner is subjected to temperature, time, and pressure conditions to ensure continuous release of the antimicrobial agent onto medical devices, using non-aqueous acrylic polymers and surfactants to control the release and maintain effective antimicrobial activity.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Duration of action of moving object

If an adequate amount of antimicrobial agent is introduced to medical kit package to maintain anti-infectious effect for sufficient period, then the duration of action is improved, but the surface properties of medical kits are adversely affected or cytotoxicity occurs

Engineering Contradiction:

Improveduration of anti-infectious effectVSAvoidsurface property degradation and cytotoxicity

Core Design Contradiction:

Duration of action of moving objectVSObject-affected harmful factors

Solution Approach 1:

The antimicrobial vehicle is segmented into multiple functional layers: a matrix layer containing the antimicrobial agent, an adhesive layer for bonding, and a release liner for protection. This segmentation allows controlled release of the antimicrobial agent while maintaining surface properties and reducing cytotoxicity through the buffering effect of multiple layers.

Inventive Principle:

Principle #1Segmentation

Solution Approach 2:

The antimicrobial vehicle is pre-applied to the medical kit package before sterilization and use. The vehicle includes a matrix layer with antimicrobial agent that is designed to release the agent in a controlled manner over time, establishing protective action in advance while minimizing adverse effects through proper formulation.

Inventive Principle:

Principle #10Preliminary action

2Reliability

If antimicrobial agent is applied to maintain desired anti-infectious activity during use in vivo, then the reliability is improved, but the loss of substance occurs during storage

Engineering Contradiction:

Improveanti-infectious activity maintenanceVSAvoidantimicrobial agent content decrease

Core Design Contradiction:

ReliabilityVSLoss of substance

Solution Approach 1:

The matrix layer provides continuous release of the antimicrobial agent over an extended period, ensuring reliable anti-infectious protection during in vivo use. The controlled release mechanism maintains therapeutic levels while minimizing total agent consumption and loss during storage.

Inventive Principle:

Principle #20Continuity of useful action

Solution Approach 2:

The formulation parameters of the antimicrobial vehicle are optimized, including the use of non-aqueous acrylic polymer adhesives and specific surfactants, to control the release rate and stability of the antimicrobial agent. These parameter changes enable maintained reliability while reducing substance loss during storage.

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The solution allows for sustained antimicrobial activity on medical devices for extended periods, reducing the risk of infection while minimizing adverse effects on the device surface properties and cytotoxicity, as demonstrated by maintaining triclosan content on suture threads for at least one year.

Implementation Method 1

a matrix type antimicrobial vehicle, comprising: a matrix layer comprising an antimicrobial agent, and an adhesive; an antimicrobial agent-releasing layer formed on one surface of the matrix layer

Methodology Applied

Scientific EffectDiffusion: Diffusion

Implementation Method 2

subjected to a temperature, time and pressure conditions including 30-80°C, 3-19 hours, and atmospheric pressure or reduced pressure to allow an effective amount of antimicrobial agent to be released from the matrix type antimicrobial vehicle toward the medical kit

Methodology Applied

Scientific EffectDissolution: Solvation

Data Source

PatentEP2658372B1Antimicrobial medical kit package and manufacturing method thereof

Publication Date: 2017.09.06 SAMYANG BIOPHARMLS CORP

Figure 1

AI summary

Provided is a matrix type antimicrobial vehicle, including: a matrix layer comprising an antimicrobial agent and an adhesive; an antimicrobial agent-releasing layer formed on one surface of the matrix layer; and a release liner formed on the other surface of the matrix layer, and a method for preparing the same. The matrix type antimicrobial vehicle is incorporated into a package having a medical kit so that the antimicrobial agent is released to the surface of medical kit or package continuously. Therefore, it is possible for the surface of the medical kit or package to maintain a constant concentration of antimicrobial agent continuously even when the medical kit or package is stored for a long time.