Antioxidant Composition Reducing C-Reactive Protein
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Solution Overview
Problem
Current treatments for oxidative stress and cardiovascular disease do not effectively reduce C-reactive protein levels in the blood, which is a marker for inflammation and oxidative stress.
Innovation Solution
A composition comprising 35-50% of a first vegetable oil with 4-12% saturated fatty acids, 35-50% of a second vegetable oil with 45-65% alpha-linolenic acid, 0.005-0.15% of Vitamin A and D, and 0.02-0.2% of antioxidants such as tocopherol, ascorbyl palmitate, or Rosemary extract, administered orally to reduce C-reactive protein levels below 1.0 mg/L in the blood.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current treatments for oxidative stress and cardiovascular disease are used, then general treatment is provided, but C-reactive protein levels are not effectively reduced
Solution Approach 1:
The patent changes the compositional parameters of the treatment by specifying precise ranges of fatty acids (omega-3, omega-6, omega-9), phytosterols, vitamins, and antioxidants to achieve effective reduction of C-reactive protein levels, moving from general treatment to targeted treatment with defined compositional parameters
Solution Approach 2:
The patent creates a composite composition combining multiple components (vegetable oils with specific fatty acid profiles, phytosterols, vitamins A and D, and antioxidants) that work synergistically to reduce oxidative stress and C-reactive protein levels, rather than using single-component treatments
2Reliability
If a composition with multiple components is used to treat oxidative stress, then therapeutic effectiveness is improved, but composition complexity increases
Solution Approach 1:
The patent manages composition complexity by defining specific parameter ranges for each component (e.g., omega-3 fatty acid content of 15-30%, phytosterol content of 2-10%, antioxidant content of 0.01-0.5%) rather than requiring precise fixed ratios, allowing flexibility while maintaining effectiveness
Solution Approach 2:
The patent uses vegetable oils that serve multiple functions: they provide the fatty acid profile needed for antioxidant activity, contribute to the overall lipid composition, and serve as a vehicle for delivering other active components (phytosterols, vitamins, and antioxidants) in the composition
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively reduces C-reactive protein levels in the blood, indicating a decrease in inflammation and oxidative stress, and has potential therapeutic benefits for cardiovascular disease.
Implementation Method 1
0.02 to 0.2 weight percent of antioxidant, wherein the antioxidant is selected from the group consisting of tocopherol, ascorbyl palmitate, Rosemary extract and mixtures thereof
Implementation Method 2
2 to 10 weight percent of at least one phytosterol
Implementation Method 3
35 to 50 weight percent of a second vegetable oil having an alpha-linolenic acid content of 45% to 65%
Implementation Method 4
0.02 to 0.2 weight percent of antioxidant, wherein the antioxidant is selected from the group consisting of tocopherol
Data Source
AI summary
The present invention, in some embodiments, is a composition that includes 35 to 50 weight percent of a first vegetable oil having a saturated fatty acid content of 4% to 12%, 35 to 50 weight percent of a second vegetable oil having an alpha-linolenic acid content of 45% to 65%, 0.005 to 0.15 weight percent of at least one of Vitamin A and Vitamin D, 2 to 10 weight percent of at least one phytosterol; and 0.02 to 0.2 weight percent of an antioxidant including, but not limited to, tocopherol, ascorbyl palmitate, Rosemary extract and mixtures thereof. The present invention further includes, in some embodiments, us of a composition for treating oxidative stress and cardiovascular diseases.