Antioxidant Composition Modulating ROS Levels
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Solution Overview
Problem
Current methods for mitigating oxidative stress are insufficient in chronic conditions, leading to various cardiovascular, neurological, and metabolic disorders, as they fail to adequately decrease reactive oxygen species (ROS) concentrations and production.
Innovation Solution
A dietary supplement composition comprising flavan-3-ols, retinoic acid, carboxylic acid, and benzopyran, such as epicatechin, vitamin A, vitamin C, and vitamin E, administered orally to decrease ROS concentrations and production, thereby modulating oxidative stress pathways.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If single antioxidant agents are used, then the treatment is simple, but the effectiveness in chronic conditions is insufficient
Solution Approach 1:
The patent combines multiple antioxidant agents with different mechanisms of action into a single composition. Specifically, it merges vitamin C (water-soluble antioxidant), vitamin E (lipid-soluble antioxidant), and flavan-3-ols (polyphenolic antioxidants) to create a synergistic formulation that addresses both aqueous and lipid environments in the body, thereby improving effectiveness in chronic conditions while maintaining ease of administration as a single product.
2Reliability
If high concentrations of ROS are present, then oxidative stress is high, but this leads to various chronic and acute pathologies
Solution Approach 1:
The patent utilizes the fact that ROS at low concentrations can be beneficial for host defense by fighting pathogens, while converting the harmful effect of excess ROS into a benefit through antioxidant treatment. The composition is designed to selectively neutralize excess ROS that cause pathology while preserving the beneficial low-level ROS signaling and pathogen-fighting capabilities of the immune system.
3Reliability
If ROS production is increased to boost host defense, then pathogen fighting capability improves, but excess ROS production leads to chronic and acute pathologies
Solution Approach 1:
The patent changes the parameter of antioxidant capacity by providing a composition with multiple antioxidants at specific concentrations that can modulate the ROS level parameter. The formulation includes vitamin C (10-100 mg), vitamin E (10-50 mg), and flavan-3-ols (5-50 mg) to achieve optimal ROS control that maintains host defense while preventing pathology.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The supplement significantly reduces ROS levels, as demonstrated by computational models and in vitro testing, effectively alleviating oxidative stress associated with conditions like cancer, cardiovascular diseases, and neurodegenerative disorders.
Implementation Method 1
one or more agents that lower the concentration reactive oxygen species
Implementation Method 2
at least one agent that decreases the concentration of ROS modulates oxidative stress pathway
Data Source
AI summary
The present disclosure is related to dietary supplements. For example, this disclosure relates to compositions that include, one or more agents that decrease the production of reactive oxygen species (ROS) responsible for oxidative stress, and/or decrease the concentration of ROS. In some embodiments, a composition as provided herein includes epicatechin present in an amount of about 0.1% to about 3% w/w of the composition; vitamin A acid present in an amount of about 1% to about 15% w/w of the composition; vitamin C present in an amount of about 10% to about 80% w/w of the composition; and, vitamin E present in an amount of about 5% to about 60% w/w of the composition. Such compositions are useful for improving oxidative stress by decreasing ROS concentration.