Antithrombotic Cell Adhesion Sheet for Tumor Detection
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Solution Overview
Problem
Current medical devices and cell separation technologies face challenges in achieving both effective antithrombotic properties to prevent blood clotting and enhanced cell adhesion, particularly for tumor cells, which is crucial for minimally invasive cancer detection and treatment.
Innovation Solution
A sheet formed using a compound with an oxyethylene repeating structure, represented by General Formula (1), is developed, which exhibits reduced platelet adhesion and improved cell adhesion properties, including tumor cell adhesion, by using a curable composition containing this compound, applied to medical devices such as stents and catheters.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a compound having an oxyethylene repeating structure is used as a coating material, then antithrombotic properties are improved, but cell adhesion properties (particularly tumor cell adhesion) are insufficient
Solution Approach 1:
The patent uses a composite material comprising a polyether compound (providing antithrombotic properties) combined with a specific polymer compound having controlled hydrophilicity. This composite coating layer simultaneously achieves blood clot prevention and enhanced tumor cell adhesion, resolving the contradiction between antithrombotic performance and cell adhesion capability
Solution Approach 2:
The patent modifies the hydrophilicity parameter of the coating material by selecting polymers with specific hydrophilic-lipophilic balance (HLB) values and molecular weights. By adjusting these parameters, the coating maintains antithrombotic properties while improving its ability to adsorb tumor cells from blood
2Reliability
If conventional coating materials are used on medical devices, then biocompatibility is improved, but tumor cell adhesion capability is insufficient for effective cancer detection
Solution Approach 1:
The patent introduces a polymer coating layer as an intermediary between the medical device surface and the blood/tumor cells. This intermediate layer mediates both biocompatibility (reducing immune rejection and thrombosis) and enhances tumor cell adhesion through controlled hydrophilic interactions, enabling sensitive cancer detection while maintaining device biocompatibility
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The sheet demonstrates excellent antithrombotic properties while enhancing cell adhesion, particularly to tumor cells, thereby supporting minimally invasive cancer detection and treatment methods with improved sensitivity and efficiency.
Implementation Method 1
a compound having an oxyethylene repeating structure [—(O—C2H5—)n-] is effective as a material for suppressing the generation of blood clots
Implementation Method 2
a method for selectively separating and recovering a target substance such as a cell, a physiologically active substance, and a protein from a body fluid such as blood
Data Source
AI summary
A first object of the present invention is to provide an antithrombotic cell adhesion sheet having excellent antithrombotic properties and cell adhesion properties. In addition, a second object of the present invention is to provide a medical device with a sheet using the antithrombotic cell adhesion sheet.The antithrombotic cell adhesion sheet of the present invention is a sheet formed b using a compound represented by General Formula (1).In General Formula (1), R1 and R4 each independently represent a hydrogen atom or a methyl group. R2 and R3 each independently represent —CH2CH(RA1)CH2—. p and r represent 1. q represents 0 or 1. m and n each independently represent an integer of 2 to 6. RA1 represents a hydrogen atom or a methyl group.