Antithrombotic Herbal Composition for Platelet Aggregation Inhibition
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Solution Overview
Problem
Current antithrombotic agents are limited by side effects such as hemorrhagic effects, gastrointestinal disorders, infertility, and hypersensitivity reactions, and there is a need for an effective agent that can inhibit thrombosis while minimizing these issues.
Innovation Solution
An antithrombotic composition using Polygonum cuspidatum Sieb. et Zucc. and Cinnamomum cassia Blume as active ingredients, extracted in a weight ratio of 1:2-2:1 or 1:1 with 70% ethanol, which is effective in inhibiting platelet aggregation and delaying thrombosis.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional antiplatelet agents (aspirin, indomethacin, etc.) are used to inhibit thrombosis, then platelet aggregation is inhibited, but hemorrhagic side effects and gastrointestinal disorders occur
Solution Approach 1:
The patent changes the chemical parameters by using natural plant extracts (Polygonum cuspidatum and Cinnamomum cassia) instead of synthetic antiplatelet agents. The extraction process using 70% ethanol at specific temperature ranges (50-70°C) and time periods (22-26 hours) optimizes the active ingredients while minimizing harmful effects, achieving antithrombotic activity without the severe side effects of conventional drugs
Solution Approach 2:
The patent combines two different plant extracts (Polygonum cuspidatum and Cinnamomum cassia) in specific weight ratios (1:2 to 2:1) to create a composite antithrombotic composition. This synergistic combination enhances the therapeutic effect while reducing individual component toxicity, thereby improving the safety profile compared to single-agent conventional drugs
2Reliability
If conventional antiplatelet agents are used to prevent thrombosis, then blood flow is maintained, but infertility and hypersensitivity reactions occur
Solution Approach 1:
The patent uses natural plant extracts that can be metabolized and eliminated by the body without accumulating to toxic levels, unlike some conventional antiplatelet agents that cause long-term side effects such as infertility and hypersensitivity. The active components from Polygonum cuspidatum and Cinnamomum cassia are naturally biodegradable, reducing the risk of chronic adverse effects
3Reliability
If Cardiotonic pills are used as antithrombotic agents, then some thrombosis inhibition is achieved, but the effect is insufficient compared to the need for stronger antithrombotic activity
Solution Approach 1:
The patent merges the antithrombotic properties of Polygonum cuspidatum and Cinnamomum cassia in optimized ratios (1:2 to 2:1 weight ratio), creating a synergistic effect that produces stronger thrombosis-delaying activity than Cardiotonic pills. The combination of different plant extracts with complementary mechanisms of action enhances the overall antithrombotic efficacy
Data Source
AI summary
The present invention relates to an antithrombotic composition including Polygonum cuspidatum Sieb. et Zucc. and Cinnamomum cassia Blume as active ingredients, and preferably includes an extract obtained by mixing Polygonum cuspidatum Sieb. et Zucc. and Cinnamomum cassia Blume in a weight ratio of 1:2-2:1 and extracting the mixture. The composition of the present invention is highly effective in antithrombotic effects, identified as a platelet aggregation inhibitory effect, a thrombosis inhibitory effect, a thrombosis-delaying effect, and the like, and thus can be used as an effective herbal-medicine-based agent for preventing or treating thrombosis, an antithrombotic health food, and the like.