Antitumor Aqueous Solution Manufacturing via Hydrogen Peroxide Feedback
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Solution Overview
Problem
Existing plasma irradiation devices struggle to determine appropriate conditions for generating an antitumor aqueous solution with a consistent antitumor effect, as the effect varies with plasma irradiation time and depends on the type of tumor.
Innovation Solution
Control the hydrogen peroxide concentration instead of directly controlling the antitumor effect, using a device that adjusts plasma irradiation conditions to achieve an appropriate antitumor effect based on the type of tumor.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If plasma irradiation time is adjusted to achieve appropriate antitumor effect, then the antitumor effect varies according to tumor type, but it is difficult to determine whether appropriate conditions are attained and difficult to select appropriate conditions
Solution Approach 1:
The system continuously monitors hydrogen peroxide concentration during plasma irradiation and uses this feedback to automatically adjust irradiation time. The control unit compares real-time concentration readings with target values and terminates irradiation when the target concentration is reached, ensuring consistent antitumor effect without requiring manual condition selection.
Solution Approach 2:
The patent transforms the control parameter from plasma irradiation time (which requires tumor-type-specific optimization) to hydrogen peroxide concentration (which directly correlates with antitumor effect). By controlling the chemical concentration parameter rather than the physical process parameter, the system achieves reliable results across different tumor types without complex condition selection.
2Reliability
If plasma irradiation conditions are optimized for specific tumor types, then appropriate antitumor effect can be achieved, but the device cannot easily adapt to different tumor types
Solution Approach 1:
The system uses hydrogen peroxide concentration as a universal indicator that correlates with antitumor effect across different tumor types. Rather than requiring tumor-type-specific irradiation protocols, the control unit maintains appropriate concentration ranges that are effective for various tumors, making the device universally applicable while maintaining reliability.
3Reliability
If plasma irradiation time is extended to increase active component concentration, then antitumor effect is enhanced, but manufacturing efficiency decreases
Solution Approach 1:
The real-time monitoring of hydrogen peroxide concentration enables precise termination of plasma irradiation when the target concentration is reached. This feedback control prevents both under-irradiation (insufficient effect) and over-irradiation (wasted time), optimizing the balance between active component concentration and manufacturing efficiency.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Manufactures an antitumor aqueous solution with a consistent active component concentration tailored to the specific tumor type, ensuring effective treatment by controlling hydrogen peroxide concentration.
Implementation Method 1
Plasma, which uses an effect of excited electrons, has been applied in various ways to fields of electricity, chemistry, materials, and medical care.
Implementation Method 2
a hydrogen peroxide concentration detection mechanism that detects a hydrogen peroxide concentration in the raw material solution
Implementation Method 3
a solution manufactured through plasma irradiation has an effect of killing a tumor
Data Source
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AI summary
The effect of an antitumor aqueous solution that is generated through plasma irradiation varies in accordance with plasma irradiation conditions, and appropriate plasma irradiation conditions depend on the type of tumor. Thus, a problem to be addressed is to provide an antitumor aqueous solution manufacturing device capable of manufacturing an antitumor aqueous solution having an appropriate antitumor effect. An antitumor aqueous solution manufacturing device (10) according to the invention for addressing the problem is a device configured to manufacture an antitumor aqueous solution having an antitumor effect, the device including a stage (26) configured to hold a raw material solution in which a raw material of the antitumor aqueous solution is dissolved; a plasma generating device (20) configured to generate plasma to be radiated on the raw material solution held by the stage (26); a hydrogen peroxide detection sensor (147) configured to measure a hydrogen peroxide concentration in the raw material solution; and a control device (38) configured to control the plasma generating device (20), the control device (38) controlling the plasma generating device (20) such that the hydrogen peroxide concentration measured by the hydrogen peroxide detection sensor (147) falls within a predetermined range.