Antiviral Polymer Surfaces With Covalent and Embedded Compounds

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Solution Overview

Problem

Current methods are inadequate in protecting surfaces and polymeric materials from viral contamination, as they lack effective antiviral properties against a wide range of viruses.

Innovation Solution

Development of antiviral surfaces and compositions by modifying polymeric molecules with specific compounds, such as those represented by formulas (I) and (II), which are covalently bonded or embedded in materials to provide antiviral activity, including the use of diazabicyclo[2.2.2]octane derivatives and modified polyols, ensuring charge balance and stability.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional surfaces and polymeric materials are used, then they maintain simplicity and ease of manufacture, but they lack effective antiviral properties against a wide range of viruses

Engineering Contradiction:
Improveantiviral propertiesVSAvoidsurface modification complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The patent modifies surfaces by changing chemical parameters - specifically by introducing quaternary ammonium groups and other cationic moieties onto polymeric surfaces. This chemical parameter change provides broad-spectrum antiviral activity while maintaining the base polymer structure, thus improving reliability without excessive complexity

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The invention creates composite surfaces by combining polymeric materials with antiviral agents (quaternary ammonium compounds, diazabicyclo[2.2.2]octane derivatives). These composite structures integrate the mechanical properties of the polymer with the antiviral functionality of the embedded compounds, achieving both durability and antiviral efficacy

Inventive Principle:
Principle #40Composite materials

2Reliability

If antiviral compounds are covalently bonded or embedded in polymeric materials, then antiviral activity is provided, but the manufacturing process becomes more complex

Engineering Contradiction:
Improveantiviral activityVSAvoidmanufacturing process
Core Design Contradiction:
ReliabilityVSEase of manufacture

Solution Approach 1:

The patent employs preliminary action by pre-synthesizing antiviral compounds with specific functional groups (quaternary ammonium, diazabicyclo[2.2.2]octane derivatives) that are designed to bond with polymeric materials. These pre-prepared compounds are then easily incorporated into the polymer matrix through straightforward processes like coating, embedding, or covalent bonding, reducing manufacturing complexity

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The invention uses small-molecule antiviral compounds that can be applied as coatings or embedded in polymers. These compounds provide antiviral protection without requiring complex structural changes to the base material, allowing for relatively simple manufacturing processes while maintaining effective antiviral activity

Inventive Principle:
Principle #27Cheap short-living objects (Disposable)

Data Source

PatentUS8999316B2Antiviral compounds
Publication Date: 2015.04.07 RES FOUND THE CITY UNIV OF NEW YORK
  • US8999316B2 patent drawing
  • US8999316B2 patent drawing
  • US8999316B2 patent drawing

AI summary

The present invention relates to novel antiviral compounds which are covalently attached to solid, macro surfaces. In another embodiment, the invention relates to novel antiviral compositions including a polymeric material and, embedded therein, an antiviral compound. In other embodiments, the invention relates to making a surface antiviral and making a polymeric material antiviral.