Antiviral Salt Compounds for Solubility and Oral Bioavailability
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Solution Overview
Problem
Existing oral drug formulations face challenges with low aqueous solubility, instability, and low permeability, leading to poor oral bioavailability and irregular distribution, which affects the effectiveness and safety of treatments for viral infections.
Innovation Solution
Development of compounds with improved solubility, stability, and permeability properties, formulated into pharmaceutical compositions for oral administration, enhancing systemic circulation and bioavailability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If oral administration is used for drug delivery, then patient compliance and convenience are improved, but oral bioavailability deteriorates due to poor physicochemical properties
Solution Approach 1:
The patent modifies the physicochemical parameters of the drug molecule by forming salt compounds with specific bases (e.g., arginine, lysine, ornithine) to improve solubility and stability while maintaining antiviral activity, thereby enhancing oral bioavailability
Solution Approach 2:
The patent creates composite pharmaceutical compositions combining the antiviral compound with pharmaceutically acceptable excipients and bases to form stable salt forms that simultaneously improve solubility, stability, and permeability properties for better oral delivery
2Reliability
If the drug molecule has high potency, then treatment effectiveness is improved, but aqueous solubility deteriorates leading to poor oral bioavailability
Solution Approach 1:
The patent changes the chemical form of the antiviral compound by forming salts with different bases, which maintains the active pharmacological moiety while improving aqueous solubility parameters for better oral absorption
3Ease of operation
If the drug is administered orally, then non-invasiveness is improved, but instability in intestinal fluid deteriorates leading to low bioavailability
Solution Approach 1:
The patent modifies the chemical stability parameters by forming salt compounds that are resistant to degradation in intestinal fluid, thereby maintaining drug integrity during oral passage while preserving non-invasive administration benefits
Data Source
AI summary
Compounds and methods of using said compounds, singly or in combination with additional agents, and salts or pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.