Antrodia Camphorata and Ganoderma Lucidum Composition for Renal Cancer
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Solution Overview
Problem
Conventional treatments for kidney failure and renal cancer, such as high-dosage steroids and target drugs, often result in significant side effects and inadequate inhibition of renal cancer cell growth, necessitating a more effective composition for enhancing kidney function and inhibiting tumor cell proliferation.
Innovation Solution
A composition comprising a water-soluble base material, a plasticity-increasing base material, Antrodia camphorata extract, Ganoderma lucidum extract, and auxiliary enzymes, formulated into a solid dispersion process to create dripping pills that inhibit renal cancer cell growth and enhance kidney function, administered at a dosage of 7 mg/day/kg for 20 days.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If high-dosage steroid is administered to treat glomerular inflammation and nephrotic syndrome, then treatment effect is improved, but side effects such as high blood glucose, moon face, buffalo shoulder, emotional instability, and abnormal adrenal hormone occur
Solution Approach 1:
The patent uses a composite formulation containing Antrodia camphorata extract, Ganoderma lucidum extract, and auxiliary enzymes as intermediary substances that mediate the treatment effect. These natural extracts serve as alternatives to conventional high-dosage steroids, providing anti-inflammatory and immunomodulatory effects without the harmful side effects associated with steroid therapy.
Solution Approach 2:
The patent changes the therapeutic parameters by using a composite natural extract formulation instead of conventional steroids. The formulation includes specific concentrations of Antrodia camphorata extract (8-15.5 wt%), Ganoderma lucidum extract (18-34 wt%), and auxiliary enzymes (1.5-3.1 wt%), which collectively provide treatment effects equivalent to high-dosage steroids without the associated toxicity.
2Reliability
If target drugs such as Sutent and Nexavar are administered to inhibit renal cancer cell growth, then tumor cell inhibition is improved, but side effects such as hand-foot syndrome, skin hyperplasia, diarrhea, fatigue, and skin peeling occur
Solution Approach 1:
The patent employs a composite natural extract formulation as an intermediary alternative to conventional target drugs. The Antrodia camphorata extract and Ganoderma lucidum extract work synergistically with auxiliary enzymes to inhibit renal cancer cell growth through natural mechanisms, avoiding the severe side effects associated with conventional targeted therapies.
Solution Approach 2:
The patent uses a composite material formulation combining multiple natural extracts and enzymes. This composite approach leverages the synergistic effects of Antrodia camphorata extract (8-15.5 wt%), Ganoderma lucidum extract (18-34 wt%), and auxiliary enzymes (1.5-3.1 wt%) to achieve enhanced tumor inhibition with reduced toxicity compared to single-agent target drugs.
3Productivity
If chemotherapy drugs are administered to treat renal cancer, then tumor growth inhibition is improved, but the drugs cannot effectively inhibit renal cancer cell growth and cause significant side effects
Solution Approach 1:
The patent introduces a composite natural extract formulation as an intermediary that enhances the effectiveness of chemotherapy while reducing side effects. The Antrodia camphorata extract, Ganoderma lucidum extract, and auxiliary enzymes work synergistically to improve tumor growth inhibition and mitigate the harmful effects of conventional chemotherapy agents.
Solution Approach 2:
The patent merges conventional chemotherapy with a composite natural extract formulation. By combining the cytotoxic effects of chemotherapy drugs with the tumor-inhibiting and protective effects of Antrodia camphorata extract, Ganoderma lucidum extract, and auxiliary enzymes, the formulation achieves enhanced productivity in tumor growth inhibition while reducing harmful side effects.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition significantly enhances kidney function by reducing blood urea nitrogen and creatinine levels and inhibits renal cancer cell growth, as demonstrated by clinical trials and cell biological experiments, offering a safer alternative to conventional therapies.
Implementation Method 1
Antrodia camphorata extract, having a third weight percent in a range from 8 wt % to 15.5 wt %; and a Ganoderma lucidum extract, having a fourth weight percent in a range from 18 wt % to 34 wt %
Implementation Method 2
an auxiliary enzyme, having a fifth weight percent in a range from 1.5 wt % to 3.1 wt %
Data Source
AI summary
The present invention provides a composition for inhibiting renal cancer cell growth and enhancing kidney function. This composition is constituted of water-soluble base material, plasticity-increasing base material, Antrodia camphorata extract, Ganoderma lucidum extract, and auxiliary enzyme. Differing from the conventional therapeutics treating the glomerulonephritis by administering high-dosage steroid for 1-4 months, the renal function of a patient suffering with serious kidney failure can be obviously enhanced after administering this composition of 7 mg/day/kg to the patient for 20 days. Moreover, because the cell biological experiments have proved that the of the present invention possess the functionality to inhibit renal cancer cell growth, this novel composition can indeed be used with chemotherapy drugs clinically, so as to solve the issue that the chemotherapy drugs cannot effectively inhibit the renal cancer cell growth.