Acousto-Optic Modulator Electrophoretic Mobility Measurement

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Solution Overview

Problem

Current electrophoretic mobility measurement instruments rely on resolving time-domain beat signals and detecting local oscillators, which are prone to mechanical vibrations and frequency shifts, limiting precision and stability.

Innovation Solution

An apparatus utilizing a long coherence length laser, fiber splitter, polarization maintaining acousto-optic modulator, sample cell, polarization maintaining combiner, photo detector, and in-phase quadrature phase demodulator to measure electrophoretic mobility by analyzing frequency shifts without resolving beat signals or local oscillators, employing RF demodulation and narrow-band filters to enhance precision.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If time-domain beat signals and local oscillators are used for measurement, then the measurement can be performed with conventional instruments, but mechanical vibrations and frequency shifts occur leading to reduced precision and stability

Engineering Contradiction:
Improveelectrophoretic mobility measurement precisionVSAvoidphase stability
Core Design Contradiction:
Measurement precisionVSReliability

Solution Approach 1:

The patent replaces mechanical vibration-prone components (moving mirrors, local oscillators) with an acousto-optic modulator that uses acoustic waves to modulate light frequency. This substitution eliminates mechanical vibrations from the optical path while achieving the same frequency shifting function, thereby improving both measurement precision and phase stability

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent introduces an acousto-optic modulator as an intermediary device between the laser source and the sample. This modulator acts as a stable frequency reference generator that does not rely on mechanical oscillators, providing a vibration-free reference signal for heterodyne detection and improving overall system reliability

Inventive Principle:
Principle #24Intermediary (Mediator)

2Measurement precision

If conventional heterodyne detection is used, then electrophoretic mobility can be measured, but mechanical vibrations limit the precision and stability of the measurement

Engineering Contradiction:
Improvefrequency shift detection precisionVSAvoidmechanical vibrations
Core Design Contradiction:
Measurement precisionVSObject-affected harmful factors

Solution Approach 1:

The patent eliminates mechanical vibration sources by replacing moving mirrors and mechanical oscillators with an acousto-optic modulator that uses sound waves in a stationary medium to achieve frequency modulation. This substitution removes the harmful mechanical vibrations while preserving the heterodyne detection capability

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent extracts and removes the mechanical vibration-prone components (local oscillators, moving mirrors) from the measurement system, retaining only the essential heterodyne detection functionality through acoustic-optic interaction, thereby eliminating the harmful mechanical vibrations from the system

Inventive Principle:
Principle #2Taking out (Extraction)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The apparatus achieves precise measurement of electrophoretic mobility by directly detecting Doppler frequency shifts, allowing for the detection of multiple mobility species and particle sizes, and simultaneously measuring electrophoretic and dynamic light scattering, with improved phase stability and reduced noise.

Implementation Method 1

a polarization maintaining acousto-optic modulator (AOM) optically coupled to a sample arm output of the splitter

Methodology Applied
Scientific EffectAcousto-optic effect: Acousto-optic Effect

Implementation Method 2

a photo detector to detect light outputted from the combiner

Methodology Applied
Scientific EffectPhotoelectric effect: Photoelectric Effect

Implementation Method 3

a long coherence length laser

Methodology Applied
Scientific EffectLight coherence: Coherent Light

Implementation Method 4

to be analyzed for shifts in frequency to measure electrophoretic mobility in the sample

Methodology Applied
Scientific EffectDoppler effect: Doppler Effect

Data Source

PatentUS20250110035A1Apparatus to measure electrophoretic mobility
Publication Date: 2025.04.03 WYATT TECHNOLOGY CORP
  • US20250110035A1 patent drawing
  • US20250110035A1 patent drawing
  • US20250110035A1 patent drawing

AI summary

The present disclosure describes an apparatus to measure electrophoretic mobility. In an embodiment, the apparatus includes a laser, a fiber splitter optically coupled to the laser, a polarization maintaining acousto-optic modulator optically coupled to a sample arm output of the splitter, a sample cell to contain a sample and optically coupled to an output of the acousto-optic modulator, a polarization maintaining combiner optically coupled to a reference arm output of the splitter and to an output of the sample cell, a photo detector to detect light outputted from the combiner, a radio frequency source electrically coupled to an input of the acousto-optic modulator, and a demodulator electrically coupled to an output of the photo detector and electrically coupled to an output of the radio frequency source, to output in-phase data and quadrature phase data to be analyzed for shifts in frequency to measure electrophoretic mobility in the sample.