Aortic Endothelial Cell Composition Mitigating Saturated Fatty Acid Inflammation

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Solution Overview

Problem

Current treatments for atherosclerosis, a major contributor to cardiovascular diseases, are often ineffective in preventing or reversing the inflammatory and mitochondrial damage that lead to this condition, particularly in aortic endothelial cells.

Innovation Solution

A composition comprising acetic acid, lactic acid, polyoxyethylene castor oil, and disodium alkyl polyoxyethylene sulfosuccinate, in specific mass ratios, is used to inhibit inflammation and protect mitochondrial function in aortic endothelial cells, reducing mRNA levels of IL-6 and MMP-1 and increasing expression of mitochondrial complexes I, III, and FoxO1 protein.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional medicine and surgery are used to treat atherosclerosis, then treatment effect is achieved, but the treatment is latent with high lethality rate and high disability rate

Engineering Contradiction:

Improvetreatment effectivenessVSAvoidlethality rate and disability rate

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent applies preliminary action by focusing on prevention and early treatment of atherosclerosis through natural active ingredients. The composition is designed to be taken before severe atherosclerotic changes occur, thereby preventing the latent and harmful effects of conventional treatments while addressing the root cause of the disease rather than just treating symptoms.

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The patent converts the harmful effects of conventional treatments (high lethality and disability rates) into benefits by using natural active ingredients that address the root cause of atherosclerosis. The composition transforms the approach from reactive treatment to proactive prevention, turning the previously harmful latent treatment effect into a beneficial early intervention strategy.

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

2Reliability

If natural active ingredients such as chlorogenic acid, Xiongshao, and lignans are used, then anti-atherosclerotic effects are achieved, but more natural substances need to be explored for effective treatment

Engineering Contradiction:

Improveanti-atherosclerotic effectVSAvoidneed for exploration of more natural substances

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent applies composite materials by combining multiple natural active ingredients (acetic acid, lactic acid, polyoxyethylene castor oil, and disodium alkyl polyoxyethylene sulfosuccinate) into a single composition. This composite approach enhances the anti-atherosclerotic effect while providing a complete treatment solution, reducing the need to explore additional natural substances.

Inventive Principle:

Principle #40Composite materials

Solution Approach 2:

The patent achieves universality by creating a multi-functional composition that addresses multiple aspects of atherosclerosis simultaneously. The composition provides anti-inflammation, mitochondrial protection, and anti-atherosclerotic effects through a single formulation, making it a universal treatment solution that reduces the need for multiple separate natural substances.

Inventive Principle:

Principle #6Universality (Multi-functionality)

3Reliability

If the composition is used to inhibit inflammation and protect mitochondria, then aortic endothelial cell function is improved, but the mechanism is complex involving multiple molecular pathways

Engineering Contradiction:

Improveaortic endothelial cell functionVSAvoidmolecular pathways involved

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent applies segmentation by dividing the complex molecular mechanisms into distinct functional modules: anti-inflammation action (reducing IL-6 and MMP-1 mRNA levels), mitochondrial protection (preventing damage from saturated fatty acids), and metabolic enhancement (increasing mitochondrial complex expression). This segmentation simplifies the understanding of how the composition improves aortic endothelial cell function through multiple coordinated pathways.

Inventive Principle:

Principle #1Segmentation

Data Source

PatentUS10576049B1Composition for improving function of aortic endothelial cell and use thereof

Publication Date: 2020.03.03 XI AN JIAOTONG UNIV

AI summary

The disclosure relates to a composition for improving aortic endothelial cell function and use thereof. The composition includes acetic acid, lactic acid, polyoxyethylene castor oil, and disodium alkyl polyoxyethylene sulfosuccinate. The composition is capable of inhibiting inflammatory response of the human aortic endothelial cells caused by saturated fatty acids, increasing a mitochondrial respiration and metabolism of vascular endothelial cells, and preventing an occurrence and progression of atherosclerosis. The composition is capable of reducing human aortic endothelial inflammation caused by saturated fatty acids, for example, reducing the mRNA levels of interleukin-6 (IL-6) and matrix metalloproteinase-1 (MMP-1), and is capable of effectively protecting the function of mitochondria in human aortic endothelium from being damaged by saturated fatty acids, for example, increasing the expression of mitochondrial complexes I and III and mitochondrial metabolism-associated Foxo1.