Aortic Stabilization Compound for Endoprosthesis Support

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Current treatments for aortic tears or dissections, such as stent placement, do not effectively address the underlying disease process, leading to continued degeneration of the aortic wall and potential complications like dissection extension.

Innovation Solution

A method involving the insertion of an endoprosthesis near the inlet flap of an aortic tear or dissection, accompanied by an infusion catheter positioned between the endoprosthesis and the aortic wall, to deliver a stabilization treatment compound that includes a contrast media agent, a stabilizing agent, and excipients, thereby stabilizing the aortic tissue.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If an endoprosthesis is placed to reduce pressure on compromised aortic tissue, then the risk of wall rupture is addressed, but the diseased portions of the aorta continue to degenerate and extend

Engineering Contradiction:

Improverisk of wall ruptureVSAvoiddegeneration of aortic tissue

Core Design Contradiction:

ReliabilityVSStability of the object's composition

Solution Approach 1:

A stabilizing compound is introduced as an intermediary substance between the endoprosthesis and the aortic tissue. This compound penetrates the aortic wall and stabilizes the tissue structure, preventing degeneration while the endoprosthesis continues to provide mechanical pressure relief. The stabilizing compound acts as a mediator that addresses the underlying tissue weakness without replacing the mechanical support function of the endoprosthesis.

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The stabilizing compound is delivered through the infusion catheter before or during the deployment of the endoprosthesis. This preliminary stabilization of the aortic tissue creates a more resilient substrate that can better withstand the hemodynamic forces, preventing future degeneration and extension of the diseased portions.

Inventive Principle:

Principle #10Preliminary action

2Stress or pressure

If a stent is placed in the true lumen to provide mechanical support, then pressure in the false lumen is reduced, but retrograde flow continues to perfuse the false lumen

Engineering Contradiction:

Improvepressure in false lumenVSAvoidretrograde flow in false lumen

Core Design Contradiction:

Stress or pressureVSObject-generated harmful factors

Solution Approach 1:

The stabilizing compound serves as an intermediary that addresses the harmful retrograde flow by strengthening the aortic wall structure. This allows the body to naturally redirect flow away from the false lumen over time as the stabilized tissue provides a more favorable pathway, eliminating the need for complex flow-diverting structures.

Inventive Principle:

Principle #24Intermediary (Mediator)

3Stress or pressure

If an endoprosthesis is implanted to bridge healthy portions of the aorta, then local hemodynamic stresses are relieved, but the distance from healthy tissue to healthy-tissue segments increases

Engineering Contradiction:

Improvehemodynamic stressesVSAvoiddistance between healthy tissue segments

Core Design Contradiction:

Stress or pressureVSLength of stationary object

Solution Approach 1:

The stabilizing compound is delivered locally to the diseased portions of the aorta through the infusion catheter positioned against the aortic wall. This localized treatment stabilizes the tissue in situ, allowing the endoprosthesis to be placed more precisely and reducing the need to bridge extensive diseased segments, thereby minimizing the distance between healthy tissue segments.

Inventive Principle:

Principle #3Local quality

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The method reduces hemodynamic pressure on diseased aortic tissue, increases stabilization near the contact point of the endoprosthesis, and reduces the spread of diseased tissue along the aortic wall, effectively addressing the limitations of current treatments.

Implementation Method 1

infusing a stabilization treatment compound through the infusion catheter

Methodology Applied

Scientific EffectInfusion:

Implementation Method 2

expanding the endoprosthesis so that the infusion catheter is in contact with aortic tissue near the inlet flap

Methodology Applied

Scientific EffectMechanical support:

Data Source

PatentUS20250049598A1Systems and methods for treating an aortic tear or dissection

Publication Date: 2025.02.13 NECTERO MEDICAL INC

AI summary

Systems and methods for treatment of an aortic tear or dissection (such as in the thoracic aortic region) are provided. Some methods disclosed herein include inserting an endoprosthesis near an inlet flap of an aortic tear or dissection, inserting an infusion catheter near the inlet flap of the aortic tear or dissection, positioning said infusion catheter between an outer surface of the endoprosthesis and an aortic wall, expanding the endoprosthesis so that the infusion catheter is in contact with aortic tissue near the inlet flap, infusing a stabilization treatment compound through the infusion catheter, wherein the stabilization treatment compound comprises a contrast media agent, a stabilizing agent, and one or more excipients, and removing the infusion catheter.