Apatite/Collagen Composite Paste for Bone Defect Filling
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Solution Overview
Problem
Existing bone repair materials, such as hydroxyapatite ceramics, are hard and brittle, making it difficult to fill bone defect portions with complicated shapes, and they have poor absorption and replacement by autogenous bone.
Innovation Solution
A powdery apatite/collagen composite with a binder, where the apatite is low-crystallinity calcium phosphate and collagen is oriented in a self-organized manner, forming a paste that can be easily shaped and implanted, promoting absorption and replacement by autogenous bone.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If hydroxyapatite ceramics are used for bone repair, then bone conduction and direct bonding to bones is achieved, but the material becomes hard and brittle, making it difficult to handle during operation
Solution Approach 1:
The patent combines hydroxyapatite particles (providing bone conduction) with collagen matrix (providing elasticity and ease of handling) to create a composite material that exhibits both bone-conductive properties and sponge-like elasticity, resolving the contradiction between reliability and ease of operation
Solution Approach 2:
The patent controls the crystallinity of hydroxyapatite (using low-crystallinity apatite instead of highly crystalline ceramics) and the ratio of hydroxyapatite to collagen to achieve optimal balance between bone conduction capability and mechanical flexibility for easy handling
2Ease of operation
If apatite/collagen composites with sponge-like elasticity are used, then ease of handling is improved, but filling bone defect portions with complicated shapes and different sizes remains difficult
Solution Approach 1:
The patent uses low-crystallinity apatite particles with specific size ranges (0.1-2.0 μm, 2.0-10 μm, or 10-20 μm) and controls the collagen matrix structure to create a material that can be molded into various shapes while maintaining ease of handling, enabling adaptation to complicated bone defect geometries
3Adaptability or versatility
If calcium phosphate cement composition is used to achieve good castability, then filling narrow or complicatedly-shaped portions is improved, but absorption and replacement by autogenous bone becomes poor
Solution Approach 1:
The patent replaces traditional calcium phosphate cement with a hydroxyapatite-collagen composite where hydroxyapatite provides bone-conductive properties for good absorption by autogenous bone, while collagen provides castability and ease of filling, resolving the contradiction between adaptability and reliability
Data Source
AI summary
An apatite/collagen composite powder absorbed and replaced by autogenous bone in the living body, a formable-to-any-shape artificial bone paste comprising an apatite/collagen composite powder and a binder, a method for producing an apatite/collagen composite powder by turning a suspension containing a fibrous apatite/collagen composite to liquid drops and rapidly cooling them, and a method for producing an apatite/collagen composite powder by granulating a blend comprising a fibrous apatite/collagen composite.