Apheresis Centrifuge Bypass Loop for Continuous Component Return
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Solution Overview
Problem
The apheresis process for blood component collection is lengthy and uncomfortable for donors due to the need to remain connected to the machine for an hour, necessitating a more efficient method to separate and return non-desired blood components without stopping and restarting the centrifuge.
Innovation Solution
A centrifuge assembly with a fluid line loop and bearing set that maintains the loop in an engaged position, allowing continuous rotation and separation of blood components, and a method to automatically load the loop, enabling the centrifuge to spin while returning separated components to the donor.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If the apheresis process uses traditional methods to separate and return blood components, then the separation can be completed, but the donation time becomes lengthy and donor comfort deteriorates
Solution Approach 1:
The patent implements continuous operation of the centrifuge throughout the entire apheresis process. The centrifuge spins continuously while blood components are separated and returned to the donor, eliminating the need to stop and restart the centrifuge multiple times. This continuous operation maintains separation forces active throughout, significantly reducing total donation time while improving donor comfort through a more streamlined process.
Solution Approach 2:
The patent positions the fluid line loop and bearing set in advance to enable continuous operation. The loop is pre-loaded and the bearing set is pre-positioned to support the loop during continuous centrifuge rotation, allowing the system to maintain separation forces without interruption and reducing overall process time.
2Reliability
If the centrifuge is stopped and restarted during component return, then component separation can be maintained, but the process complexity increases and time is lost
Solution Approach 1:
The patent eliminates the stop-start cycle by implementing continuous centrifuge operation. The bearing set supports the fluid line loop during continuous rotation, allowing separation forces to remain active throughout the entire process including during component return, thereby simplifying the operational sequence while maintaining reliable separation.
Solution Approach 2:
The bearing set acts as an intermediary mechanism that enables continuous centrifuge operation. It supports the fluid line loop during rotation, allowing the system to maintain separation forces without interruption while facilitating the return of blood components to the donor.
3Speed
If the fluid line loop is not properly positioned, then the centrifuge cannot rotate continuously, but the positioning mechanism adds complexity
Solution Approach 1:
The bearing set serves as an intermediary positioning mechanism that simplifies loop placement. It provides a defined position for the fluid line loop during continuous centrifuge rotation, enabling smooth operation without complex positioning systems while maintaining rotational continuity.
Solution Approach 2:
The bearing set automatically positions and supports the fluid line loop during continuous rotation. The loop is held in the correct position by the bearing set's structure, eliminating the need for complex active positioning mechanisms and enabling seamless continuous operation.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The process is made more efficient, reducing donation time by up to 30% and enhancing donor comfort, thereby increasing donation center productivity and donor return rates.
Implementation Method 1
a centrifuge assembly with a fluid line loop and bearing set that maintains the loop in an engaged position, allowing continuous rotation and separation of blood components
Data Source
AI summary
Described are embodiments that include methods and devices for separating components from multi-component fluids. Embodiments may involve use of separation vessels and movement of components into and out of separation vessels through ports. Embodiments may involve the separation of plasma from whole blood. Also described are embodiments that include methods and devices for positioning portions, e.g., loops, of disposables in medical devices. Embodiments may involve use of surfaces for automatically guiding loops to position them into a predetermined position.