Apheresis System Peristaltic Pump Controlled Solution Addition
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Solution Overview
Problem
Aphaeresis systems face challenges in reducing operator intervention and error, improving collection efficiency, and minimizing adverse effects on blood components, which affect commercial viability and product quality.
Innovation Solution
The system incorporates a controlled addition of storage solutions to red blood cells or platelets using a self-priming mechanism with peristaltic pumps and sensors to ensure accurate metering, reducing operator dependency and trauma to blood components.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If manual addition of storage solution is used, then operator control is maintained, but operator error and intervention time increase
Solution Approach 1:
The system performs self-priming of the peristaltic pump by automatically detecting air bubbles in the tubing and reversing pump rotation to expel them, eliminating the need for manual priming intervention while maintaining system simplicity
Solution Approach 2:
Optical sensors detect the presence of air bubbles or fluid in the tubing and provide feedback signals to the controller, which automatically adjusts pump operation to maintain proper fluid flow without operator intervention
2Productivity
If rapid collection is pursued, then productivity increases, but collection efficiency may be compromised
Solution Approach 1:
The system pre-calculates and pre-sets the storage solution addition volume based on the anticipated blood component collection volume, allowing rapid collection to proceed without interruption while ensuring accurate solution addition occurs at the optimal moment
Solution Approach 2:
The peristaltic pump operates continuously during both blood component collection and storage solution addition without stopping, maintaining uninterrupted flow and eliminating idle time that would reduce productivity
3Loss of time
If storage solution is added during collection, then processing time is reduced, but mixing precision may be compromised
Solution Approach 1:
The system replaces manual mixing operations with a controlled peristaltic pump delivery system that uses rotational counting to precisely meter the storage solution volume, achieving both speed and precision simultaneously
Solution Approach 2:
The system uses optical sensors to detect fluid characteristics and verify the presence and volume of storage solution added, providing automated verification that ensures mixing accuracy without requiring manual measurement
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enhances operational efficiency, reduces operator error, and improves the quality of collected blood components by ensuring precise addition of storage solutions, thereby increasing productivity and donor convenience.
Implementation Method 1
peristaltic pumps, which move a known quantity of fluid per pump revolution
Data Source
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AI summary
A centrifugal blood processing apparatus comprising a centrifuge rotor (20), a separation chamber (12), a tubing set (8) for conducting blood components and fluids and having an inlet line, an outlet line (50) and a storage solution line (122) in fluid communication with the outlet line at a junction. The apparatus controls pumps to conduct a predetermined quantity of storage solution to a collected blood component. The apparatus also purges blood components in the tubing set by applying a negative pressure and positive pressure. A disposable blood processing set has a separation chamber; a tubing set including an inlet line in fluid and an outlet and a storage solution line connected to the outlet line at a junction.