Multi-Extract Aphrodisiac Composition for Sexual Dysfunction
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Solution Overview
Problem
Current treatments for male sexual dysfunction do not effectively target all aspects of the condition, leading to relapse and are often associated with side effects or discomfort, highlighting an unmet need for a safe and efficient therapeutic management solution.
Innovation Solution
A composition comprising 60-65% Withania somnifera extract standardized to contain 0.25% withaferin and 7% withanolides, 12-18% Mucana pruriens extract standardized to contain 10% L-dopa, 5-10% Coleus forskohlii extract standardized to contain 10% forskolin, 12-18% Kaempferia parviflora extract standardized to contain 2.5% 5,7-dimethoxyflavone, and 0.1-2% Piper nigrum extract standardized to contain 95% Piperine, which increases nitric oxide, testosterone, and cGMP levels, acting as a synergistic aphrodisiac and therapeutic agent.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If state of the art chemical compositions (PDE5 inhibitors, botulinum toxin) are used to treat male sexual dysfunction, then erectile function is improved, but side effects and discomfort occur
Solution Approach 1:
The patent combines multiple plant extracts (Withania somnifera, Mucuna pruriens, Coleus forskohlii, Kaempferia parviflora, Piper nigrum) with specific standardized phytochemical concentrations to create a composite formulation that achieves therapeutic effects while minimizing side effects associated with conventional chemical treatments
Solution Approach 2:
The invention standardizes the concentration of key phytochemicals (withaferin A at 0.25%, withanolides at 7%, L-dopa at 10%, forskolin at 10%, 5,7-dimethoxyflavone at 2.5%, piperine at 95%) to optimize therapeutic efficacy and reduce adverse effects compared to non-standardized herbal preparations
2Reliability
If current treatments for male sexual dysfunction are used, then some aspect of the condition is addressed, but the treatment does not effectively target all aspects leading to relapse
Solution Approach 1:
The multi-component plant extract formulation addresses multiple pathways involved in sexual dysfunction simultaneously (nitric oxide production, testosterone synthesis, cGMP elevation, smooth muscle relaxation, blood flow enhancement), providing comprehensive therapeutic management that prevents relapse by targeting all aspects of the condition
3Reliability
If plant extracts and phytochemicals are used to increase nitric oxide and cGMP levels, then penile blood flow and smooth muscle relaxation are improved, but the composition complexity increases
Solution Approach 1:
The formulation is divided into distinct plant extract components, each standardized for specific phytochemical content, allowing for systematic control of nitric oxide and cGMP elevation while maintaining manageable composition through defined segments rather than a monolithic complex mixture
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition significantly enhances libido, improves erectile function, and prolongs sexual satisfaction by inhibiting phosphodiesterase-5, enhancing nitric oxide and cGMP levels, and activating androgen receptors, as demonstrated by increased mounting behavior, testosterone, and cGMP levels in male wistar rats, indicating a safe and effective management of male sexual dysfunction.
Implementation Method 1
Nitric oxide stimulates the enzyme guanylate cyclase that converts GTP to 3′, 5′-cyclic guanosine monophosphate (cGMP)
Implementation Method 2
Ideally the cGMP is converted into 5′ GMP by phospho diesterase enzyme, thus reducing the erection
Data Source
AI summary
The present invention discloses a composition for the therapeutic management of male sexual dysfunction and related disorders. Specifically, the invention discloses a composition comprising 60-65% w/w Withania somnifera extract, 12-18% w/w Mucana pruriens extract, 5-10% w/w Coleus forskolii extract, 12-18% w/w Kaempferia parviflora extract, 0.1-2% w/w Piper nigrum extract, for use as an aphrodisiac.