Apigenin C-Glycosides for Pinellic Acid Bitter Blocking

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Solution Overview

Problem

Whole grain foods are often associated with negative flavor attributes such as graininess, bitterness, and oxidized aroma notes, limiting their consumption despite their health benefits.

Innovation Solution

Incorporation of apigenin glycosides, particularly C-glycosides, to modulate flavors and reduce bitter tastes by blocking the formation of pinellic acid, a key contributor to bitterness in whole grains.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If whole grain foods are consumed to gain health benefits, then health value is improved, but flavor quality deteriorates due to bitterness and negative taste attributes

Engineering Contradiction:
Improvehealth benefitVSAvoidbitterness and negative flavor attributes
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

Apigenin C-glycosides act as intermediary compounds that selectively interact with pinellic acid through hydrogen bonding and hydrophobic interactions, forming a complex that reduces pinellic acid's bitter taste perception without affecting the nutritional components of whole grains. This mediator approach allows simultaneous preservation of health benefits and improvement of flavor quality.

Inventive Principle:
Principle #24Intermediary (Mediator)

Solution Approach 2:

The invention changes the chemical parameter profile of whole grain products by introducing apigenin C-glycosides, which alter the taste perception parameters through specific molecular interactions with pinellic acid. This parameter change approach transforms the bitter taste profile while maintaining the original nutritional composition.

Inventive Principle:
Principle #35Parameter changes

2Adaptability or versatility

If natural whole grain ingredients are used, then product naturalness is improved, but manufacturing complexity increases due to flavor modification requirements

Engineering Contradiction:
Improveproduct naturalnessVSAvoidmanufacturing process complexity
Core Design Contradiction:
Adaptability or versatilityVSDevice complexity

Solution Approach 1:

Apigenin C-glycosides are incorporated into the whole grain product formulation during the manufacturing process, performing the flavor modification action preliminarily before the product reaches the consumer. This preliminary action eliminates the need for post-processing flavor adjustments and simplifies the overall manufacturing workflow while maintaining product naturalness.

Inventive Principle:
Principle #10Preliminary action

3Object-affected harmful factors

If apigenin C-glycosides are added to reduce bitterness, then flavor quality is improved, but device complexity increases due to additional ingredient incorporation

Engineering Contradiction:
Improvebitterness reductionVSAvoidformulation complexity
Core Design Contradiction:
Object-affected harmful factorsVSDevice complexity

Solution Approach 1:

Apigenin C-glycosides serve multiple functions simultaneously: they act as flavor modifiers by complexing with pinellic acid, function as potential antioxidants, and maintain compatibility with various whole grain product formulations. This multi-functionality reduces the need for additional separate additives, thereby limiting the increase in formulation complexity while achieving bitterness reduction.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Significantly reduces perceived bitterness and pinellic acid levels in whole grain products, enhancing their flavor profile and consumer acceptance.

Implementation Method 1

Incorporation of apigenin glycosides, particularly C-glycosides, to modulate flavors and reduce bitter tastes by blocking the formation of pinellic acid

Methodology Applied
Scientific EffectChemical interaction: Chemical Bonding

Data Source

PatentUS12527339B2Apigenin glycosides flavor enhancers
Publication Date: 2026.01.20 OHIO STATE INNOVATION FOUND
  • US12527339B2 patent drawing
  • US12527339B2 patent drawing
  • US12527339B2 patent drawing

AI summary

Disclosed herein are compounds and methods useful for improving the flavor and suppressing bitter sensations is a variety of food products, including cereals and grains such as wheat.