Apoaequorin and Vitamin D Composition for Calcium Homeostasis
Solution Overview
Problem
Current therapeutic options for calcium imbalance and vitamin D deficiency often come with unwanted side effects, necessitating the development of alternative compositions that effectively alleviate or prevent these conditions with reduced adverse reactions.
Innovation Solution
Compositions combining apoaequorin and vitamin D, administered in various forms such as tablets, capsules, or solutions, to maintain calcium homeostasis and vitamin D levels, potentially including additional nutraceutical agents for enhanced benefits, targeting symptoms like sleep quality, energy, mood, and memory.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If calcium channel antagonists are used to treat calcium imbalance, then calcium-related disorders are prevented, but unwanted side effects occur
Solution Approach 1:
The patent extracts and utilizes apoaequorin, a calcium-binding protein naturally derived from jellyfish, as an alternative therapeutic agent. This natural protein selectively binds calcium ions without triggering the side effects associated with synthetic calcium channel antagonists, thereby treating calcium imbalance while avoiding harmful effects on cardiac and smooth muscle function
Solution Approach 2:
Apoaequorin serves as a natural intermediary that mediates calcium binding and regulation. The protein acts as a buffer for calcium ions in the bloodstream, gradually regulating calcium levels through its high-affinity binding sites, thereby providing a gentler and safer alternative to direct calcium channel blockade
2Reliability
If vitamin D supplementation is provided to maintain calcium homeostasis, then calcium absorption is improved, but inadequate efficacy is achieved when used alone
Solution Approach 1:
The patent combines apoaequorin and vitamin D in a single composition to achieve synergistic therapeutic effects. Apoaequorin provides immediate calcium binding and buffering capacity, while vitamin D enhances intestinal calcium absorption over time. This combination addresses both acute and chronic aspects of calcium homeostasis more effectively than either agent alone
Solution Approach 2:
The invention creates a composite therapeutic composition containing both apoaequorin protein and vitamin D compound. This composite formulation leverages the complementary mechanisms of action between the two active ingredients, where apoaequorin's high-affinity calcium binding works in conjunction with vitamin D's calcium absorption enhancement to achieve superior therapeutic outcomes
Data Source
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AI summary
Compositions containing apoaequorin and vitamin D and methods for their use in treating symptoms and disorders related to calcium imbalances and vitamin D deficiency associated with, for example, sleep quality, energy quality, mood quality, memory quality or pain are provided by the present invention