Apparatuses, systems, and methods for storing and transporting a temperature sensitive material

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Solution Overview

Problem

Current technologies for transporting apheresis materials are inadequate due to high failure rates, inability to maintain precise temperature ranges, and lack of user-friendly operation and monitoring features, leading to logistical challenges and potential damage to samples.

Innovation Solution

A system comprising a shipping container with a storage container that uses phase change material, thermoelectric coolers, and a heat exchanger to maintain temperature control, along with a control system and environmental monitoring system for real-time tracking and condition management.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Temperature

If evaporative on-demand cooling shippers are used, then temperature control is provided, but failure rates are high and temperature range maintenance is unreliable

Engineering Contradiction:
Improvetemperature controlVSAvoidfailure rate
Core Design Contradiction:
TemperatureVSReliability

Solution Approach 1:

The cooling system is segmented into multiple independent components: phase change material modules, thermoelectric cooler modules, and heat exchanger modules. Each module operates independently to maintain temperature, so if one module fails, others continue to function, reducing overall system failure rate.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The system uses composite cooling technology combining phase change materials (for passive thermal regulation) with thermoelectric coolers (for active temperature control). This composite approach leverages the strengths of both materials to achieve reliable temperature maintenance across varying conditions.

Inventive Principle:
Principle #40Composite materials

2Reliability

If vacuum insulated shippers with phase change material or ice are used, then failure rates are lower, but pre-conditioning requirements increase complexity and reduce on-demand availability

Engineering Contradiction:
Improvefailure rateVSAvoidpre-conditioning requirement
Core Design Contradiction:
ReliabilityVSEase of operation

Solution Approach 1:

The system automatically performs pre-conditioning operations through its control system that monitors temperature and activates cooling modules as needed. The microprocessor-controlled system self-regulates the pre-cooling phase without requiring manual intervention or specialized knowledge from operators.

Inventive Principle:
Principle #25Self-service

Solution Approach 2:

Manual pre-conditioning operations are replaced with an automated electronic control system featuring a microprocessor that monitors temperature sensors and controls cooling module activation. This substitution eliminates the need for staff to understand complex pre-conditioning procedures.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

3Temperature

If existing vacuum insulated shippers are used, then cooling performance is provided, but location tracking and real-time monitoring features are lacking

Engineering Contradiction:
Improvecooling performanceVSAvoidlocation tracking capability
Core Design Contradiction:
TemperatureVSLoss of information

Solution Approach 1:

The shipping container integrates multiple functions into a single system: thermal insulation, active cooling, temperature monitoring, GPS location tracking, and wireless data communication. This multi-functional design ensures cooling performance while simultaneously providing real-time location and condition information.

Inventive Principle:
Principle #6Universality (Multi-functionality)

4Ease of manufacture

If currently available storage and shipping systems are used, then basic storage is provided, but operational complexity requires expert understanding and increases logistical errors

Engineering Contradiction:
Improvebasic storage capabilityVSAvoidoperational complexity
Core Design Contradiction:
Ease of manufactureVSEase of operation

Solution Approach 1:

The system performs self-diagnosis and self-regulation through integrated sensors and a microprocessor control system that automatically adjusts cooling operations. This eliminates the need for operators to understand complex pre-conditioning procedures or system mechanics.

Inventive Principle:
Principle #25Self-service

Solution Approach 2:

Temperature sensors continuously monitor the internal environment and provide feedback to the control system, which automatically adjusts cooling module operation. This closed-loop feedback mechanism simplifies operation by eliminating manual monitoring and adjustment requirements.

Inventive Principle:
Principle #23Feedback

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The system ensures reliable and efficient transportation of apheresis materials by maintaining precise temperature control, reducing failure rates, and enabling real-time monitoring and tracking, thus ensuring sample viability and reducing logistical errors.

Implementation Method 1

the insert comprises phase change material

Methodology Applied
Scientific EffectPhase change: Phase Change

Implementation Method 2

thermoelectric coolers

Methodology Applied
Scientific EffectPeltier effect: Peltier Effect

Implementation Method 3

heat exchanger to maintain temperature control

Methodology Applied
Scientific EffectHeat exchanger: Heat Exchanger

Implementation Method 4

the housing includes an exterior wall joined to an interior wall forming a vacuum therebetween

Methodology Applied
Scientific EffectVacuum thermal insulation: Vacuum

Data Source

PatentUS20250043998A1Apparatuses, systems, and methods for storing and transporting a temperature sensitive material
Publication Date: 2025.02.06 KITE PHARMA INC
  • US20250043998A1 patent drawing
  • US20250043998A1 patent drawing
  • US20250043998A1 patent drawing

AI summary

The present disclosure describes storing and transporting technologies for temperature sensitive materials. More specifically, storage and transport of apheresis material. The described technologies include environmental monitoring systems, location tracking systems, an environmental control system, and customized systems and interfaces allowing for non-expert use. The storing and transporting technologies described herein may be ideally suited for the unique requirements of apheresis material.