Appendix-Cecum Probiotic Indwelling Device for Flora Treatment
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Solution Overview
Problem
Existing methods for improving the enteric environment through orally taken probiotics are limited in effectiveness and efficiency, particularly in targeting specific regions of the gastrointestinal tract like the appendix and cecum, and are susceptible to interference from indigenous bacteria.
Innovation Solution
An indwelling device comprising probiotics and a carrier with a first region in the appendix and a second region in the cecum, optionally with an antibacterial agent, is introduced using an endoscope to ensure prolonged contact and protection of the probiotics, utilizing bioabsorbable materials and designs to enhance proliferation and migration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If probiotics are orally taken to improve enteric environment, then probiotics can reach the gastrointestinal tract, but the effectiveness is limited due to interference from indigenous bacteria and inability to target specific regions
Solution Approach 1:
The indwelling device is divided into multiple regions: a first region containing probiotics arranged in the appendix, and a second region containing an antibacterial agent arranged in the cecum. This segmentation allows targeted delivery of probiotics to specific gastrointestinal regions while locally suppressing indigenous bacteria with the antibacterial agent, thereby resolving the contradiction between probiotic effectiveness and bacterial interference.
Solution Approach 2:
The antibacterial agent acts as an intermediary substance that creates a favorable environment for probiotics by suppressing indigenous bacteria in the cecum. This mediator enables the probiotics in the appendix to thrive without competition from harmful bacteria, improving overall effectiveness while managing bacterial interference.
2Adaptability or versatility
If probiotics are delivered to specific regions like appendix and cecum, then targeted treatment is achieved, but the device complexity increases
Solution Approach 1:
The indwelling device performs multiple functions within a single structure: it delivers probiotics to the appendix, provides antibacterial action in the cecum, and maintains prolonged contact with the gastrointestinal mucosa. This multi-functionality achieves targeted regional treatment without requiring multiple separate devices, thereby managing device complexity while improving adaptability.
Solution Approach 2:
Different regions of the indwelling device have different functional properties: the first region is optimized for probiotic delivery to the appendix, while the second region contains antibacterial agents for cecum treatment. This local differentiation enables targeted treatment of specific gastrointestinal regions while maintaining a relatively simple overall device structure.
3Duration of action of moving object
If probiotics are placed in contact with appendico inner surface, then prolonged contact and proliferation is enhanced, but the probiotics may be contaminated or deactivated
Solution Approach 1:
The antibacterial agent is pre-positioned in the second region (cecum) to suppress indigenous bacteria before the probiotics in the first region (appendix) are exposed to the gastrointestinal environment. This preliminary action protects the probiotics from contamination and deactivation, allowing them to maintain prolonged contact with the appendico inner surface while ensuring their survival and proliferation.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The indwelling device effectively delivers probiotics to the appendix and cecum, enhancing the enteric flora and immune system while minimizing interference from indigenous bacteria, thereby improving gut health and immune function.
Implementation Method 1
ensure prolonged contact and protection of the probiotics, utilizing bioabsorbable materials and designs to enhance proliferation and migration
Implementation Method 2
the second region contains an antibacterial agent
Implementation Method 3
utilizing bioabsorbable materials and designs to enhance proliferation and migration
Data Source
AI summary
An indwelling device for treating flora includes probiotics, a carrier carrying the probiotics and including a first region arranged in an appendico and a second region arranged in an intestinal cecum, in which the probiotics are carried in the first region and the second region contains an antibacterial agent.