Nucleic Acid Aptamer Binding to Surfaces in Consumer Products
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Solution Overview
Problem
There is a need for nucleic acid aptamers with high binding affinity and specificity for consumer product applications, particularly those containing surfactants, as existing aptamers struggle with binding to macroscopic materials and surfaces in the presence of surfactants.
Innovation Solution
The development of consumer product compositions that include a surfactant and a nucleic acid aptamer, where the aptamer is designed to bind specifically to surfaces such as teeth, and can be covalently or non-covalently attached to active ingredients or nanomaterials to enhance delivery and efficacy.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing aptamers are used in consumer products containing surfactants, then the product can provide general cleaning functions, but the aptamers lose binding affinity and specificity to target surfaces
Solution Approach 1:
The patent modifies the chemical structure of the aptamer by incorporating chemically modified nucleotides (such as 2'-O-methyl, 2'-fluoro, phosphorothioate) to change its physical and chemical parameters. These modifications enhance the aptamer's resistance to surfactant interference while maintaining its binding affinity and specificity to target surfaces like teeth.
2Measurement precision
If aptamers are designed for high specificity to target surfaces, then binding precision improves, but the complexity of aptamer design and selection increases
Solution Approach 1:
The patent employs a pre-designed library of aptamers with specific sequences (SEQ ID NOs: 1, 9, 25, 112, 120, 136) that have been previously selected and optimized for high specificity to target surfaces. This preliminary action eliminates the need for complex, de novo aptamer selection processes while ensuring high binding precision.
Solution Approach 2:
The patent uses chemically modified nucleotides as intermediaries to facilitate the binding between the aptamer and target surface. These modified nucleotides act as mediators that enhance the stability and specificity of the aptamer-target interaction while simplifying the overall design process.
3Productivity
If aptamers are attached to active ingredients for targeted delivery, then delivery efficiency to surface improves, but the complexity of product formulation increases
Solution Approach 1:
The patent combines the aptamer and active ingredient into a single conjugate molecule through covalent attachment. This merging of two separate components (aptamer for targeting and active ingredient for function) into one unified structure simplifies the formulation process while maintaining high delivery efficiency to the target surface.
Solution Approach 2:
The patent creates a composite material consisting of the aptamer-active ingredient conjugate. This composite structure integrates the targeting capability of the aptamer with the functional properties of the active ingredient, resulting in a simplified yet highly effective product formulation that achieves precise delivery to the target surface.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The use of these aptamers in consumer product compositions enables efficient delivery of active ingredients to targeted surfaces, improving the effectiveness and specificity of the products, even in the presence of surfactants.
Implementation Method 1
The molecular recognition of aptamers is based on structure compatibility and intermolecular interactions
Implementation Method 2
including electrostatic forces, van der Waals interactions, hydrogen bonding, and π-π stacking interactions
Implementation Method 3
including electrostatic forces, van der Waals interactions, hydrogen bonding, and π-π stacking interactions
Implementation Method 4
including electrostatic forces, van der Waals interactions, hydrogen bonding, and π-π stacking interactions
Implementation Method 5
including electrostatic forces, van der Waals interactions, hydrogen bonding, and π-π stacking interactions
Implementation Method 6
consumer product compositions comprising a surfactant and a nucleic acid aptamer
Data Source
Figure 1~2
Figure 3A~3B
Figure 3C~3D
AI summary
Consumer product compositions comprise a surfactant and a nucleic acid aptamer. The nucleic acid aptamer comprises at least one oligonucleotide comprising: deoxyribonucleotides, ribonucleotides, derivatives of deoxyribonucleotides, derivatives of ribonucleotides, or mixtures thereof. The nucleic acid aptamer has a binding affinity for an epitope of a surface being treated with the consumer product composition.