Aptamer-Vitamin C Complex Stabilization
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Solution Overview
Problem
Vitamin C, a widely used antioxidant, is prone to oxidation due to its high reducing power and sensitivity to environmental factors, leading to rapid degradation and loss of effectiveness in cosmetics, nutritional supplements, and food products, which limits their storage period and efficacy.
Innovation Solution
A method using nucleotide aptamers to inhibit the oxidation of vitamin C by binding to its lactone ring, forming an aptamer-vitamin C complex that is incorporated into hydrogels, allowing controlled release and maintaining the reduced state of vitamin C, thereby extending its antioxidant function.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If vitamin C is used as an antioxidant in cosmetics and nutritional supplements, then antioxidant activity is improved, but oxidation stability deteriorates
Solution Approach 1:
The patent introduces aptamers as intermediary molecules that bind to vitamin C through specific recognition of the lactone ring structure. This aptamer-vitamin C complex acts as a mediator that protects vitamin C from direct oxidation while maintaining its antioxidant function, resolving the contradiction between antioxidant activity and oxidation stability
Solution Approach 2:
The patent creates a composite system consisting of aptamers and vitamin C molecules. This composite material combines the stabilizing properties of aptamers with the antioxidant properties of vitamin C, achieving both oxidation stability and antioxidant activity simultaneously
2Reliability
If vitamin C is applied to skin for antioxidant protection, then skin aging prevention is improved, but storage period deteriorates
Solution Approach 1:
The patent applies preliminary protection by pre-binding vitamin C to aptamers before application to the skin. This preliminary complex formation protects vitamin C from oxidation during storage and transport, ensuring the product remains effective throughout its shelf life while maintaining skin protection capabilities
3Productivity
If vitamin C is used in high concentration for maximum antioxidant effect, then antioxidant efficiency is improved, but oxidation rate deteriorates
Solution Approach 1:
The patent uses aptamers as protective intermediaries that bind to vitamin C molecules. This allows the use of high vitamin C concentrations for maximum antioxidant effect while the aptamers prevent rapid oxidation, thus maintaining both antioxidant efficiency and slowing oxidation rate
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The aptamer-vitamin C complex effectively stabilizes vitamin C, maintaining its antioxidant function for a longer time and enhancing the stability and efficacy of cosmetic and nutritional formulations, while allowing controlled release based on skin conditions or environmental stimuli.
Implementation Method 1
maintaining the reduction power thereof by binding to the lactone ring of vitamin C
Data Source
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AI summary
The present disclosure relates to a method for preventing oxidation of an antioxidant material, the material, and a use thereof and, more specifically, to a method for preventing oxidation of an antioxidant material by treating the antioxidant material with aptamer, to an aptamer having such activity, and to an application to various fields, such as medical products, cosmetic products, and food, using the aptamer. The aptamer of the present disclosure has an effect of preventing oxidation of an antioxidant material, such as vitamin C, and therefor, the aptamer of the present disclosure can be applied to various fields, such as medical products, cosmetic products, and food, in need of prevention of the oxidation of the antioxidant material.