Aqueous Dianhydrohexitol Packaging to Prevent Degradation and Caking

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Solution Overview

Problem

Existing methods for packaging dianhydrohexitols, particularly isosorbide, are complex, expensive, and unsuitable for large quantities, leading to chemical degradation and caking issues, especially in food and pharmaceutical applications where minimal antioxidants are required.

Innovation Solution

Packaging dianhydrohexitols in the form of an aqueous solution using a single layer of polyolefin-based material with minimal or no antioxidants, maintaining a dry matter content between 40% and 95%, and ensuring stability through a simple, cost-effective process.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Stability of the object's composition

If dianhydrohexitol is packaged in solid form using gas-impermeable packaging materials under reduced oxygen and nitrogen pressure, then chemical stability is improved, but device complexity and manufacturing cost increase significantly

Engineering Contradiction:
Improvechemical stabilityVSAvoidpackaging complexity
Core Design Contradiction:
Stability of the object's compositionVSDevice complexity

Solution Approach 1:

The patent changes the physical state parameter of dianhydrohexitol from solid to aqueous solution form. This parameter change fundamentally alters the packaging requirements, allowing the use of simple polyethylene bags without complex gas-impermeable layers or reduced pressure conditions, while maintaining chemical stability during storage and transport.

Inventive Principle:
Principle #35Parameter changes

Solution Approach 2:

The patent employs inexpensive, single-use polyethylene packaging bags instead of complex, expensive gas-impermeable packaging systems. The simple polyethylene material, typically used for short-term storage, effectively protects aqueous dianhydrohexitol solutions without requiring sophisticated packaging infrastructure.

Inventive Principle:
Principle #27Cheap short-living objects (Disposable)

2Ease of manufacture

If dianhydrohexitol is packaged in solid form using traditional polyethylene packaging, then packaging simplicity is improved, but chemical degradation occurs leading to formic acid formation

Engineering Contradiction:
Improvepackaging simplicityVSAvoidchemical stability
Core Design Contradiction:
Ease of manufactureVSStability of the object's composition

Solution Approach 1:

The patent changes the physical state parameter of dianhydrohexitol from solid to aqueous solution form. This parameter change fundamentally alters the packaging requirements, allowing the use of simple polyethylene bags without complex gas-impermeable layers or reduced pressure conditions, while maintaining chemical stability during storage and transport.

Inventive Principle:
Principle #35Parameter changes

3Stability of the object's composition

If antioxidants are added to packaging material to improve dianhydrohexitol stability, then chemical stability is improved, but antioxidant content increases which is problematic for food and pharmaceutical applications

Engineering Contradiction:
Improvechemical stabilityVSAvoidantioxidant content
Core Design Contradiction:
Stability of the object's compositionVSQuantity of substance

Solution Approach 1:

The patent changes the physical state parameter of dianhydrohexitol from solid to aqueous solution form and adjusts the water content parameter. This parameter change eliminates the need for antioxidants in packaging material, as the aqueous solution form inherently maintains stability without requiring additional antioxidant substances, thus meeting food and pharmaceutical application requirements.

Inventive Principle:
Principle #35Parameter changes

4Productivity

If solid dianhydrohexitol is packaged in large quantities, then productivity is improved, but caking issues occur during storage

Engineering Contradiction:
Improvepackaging efficiencyVSAvoidphysical stability
Core Design Contradiction:
ProductivityVSStability of the object's composition

Solution Approach 1:

The patent changes the physical state parameter of dianhydrohexitol from solid to aqueous solution form. This parameter change eliminates caking issues entirely, as the liquid solution maintains uniform composition and flow properties during storage and transport, allowing efficient packaging of large quantities without physical degradation.

Inventive Principle:
Principle #35Parameter changes

Data Source

PatentEP3194295B1Method for conditioning a dianhydrohexitol, aqueous solution of conditioned dianhydrohexitol, and uses thereof
Publication Date: 2025.07.23 ROQUETTE FRERES SA

AI summary

The invention relates to a method for conditioning a dianhydrohexitol in the form of an aqueous solution in a container comprising a polyolefin-based layer. The invention also relates to the aqueous solution of thus-conditioned dianhydrohexitol, and to all the uses thereof, in particular those intended for food and pharmaceutical purposes.