Aqueous Dispersion Sustained Release Antimicrobial
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Solution Overview
Problem
Current delivery systems for biologically active compounds, such as hand sanitizers, provide transient antimicrobial effects, leading to frequent reapplication and side effects like skin irritation and toxicity, and fail to maintain prolonged microbial reduction, especially in healthcare settings where sustained protection is crucial.
Innovation Solution
Development of aqueous dispersions with a hydrophilic submicron particle substrate and a quaternary ammonium compound that forms a complex with the active agent, allowing for sustained release and reduced toxicity, incorporating humectants and emollients for skin compatibility and extended adherence.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If high doses or frequent reapplication are used to achieve prolonged effects, then antimicrobial activity is improved, but skin irritation and toxicity increase
Solution Approach 1:
The patent uses a carrier system comprising a surfactant and a polymer to mediate between the active antimicrobial compound and the skin. This carrier system allows controlled release of the active compound, maintaining effective concentrations over time without requiring high doses or frequent reapplication, thereby reducing skin irritation and toxicity while prolonging antimicrobial activity
Solution Approach 2:
The patent changes the physical and chemical parameters of the delivery system by using specific surfactant-polymer combinations that enable sustained release. The carrier system modifies the release kinetics of the active compound, transforming transient antimicrobial action into prolonged effect without increasing the total dose, thus reducing harmful effects on skin
2Speed
If alcohol-based hand sanitizers are used for rapid antimicrobial action, then immediate kill rate is improved, but residual protection and persistence are reduced
Solution Approach 1:
The patent creates a continuous release system where the active antimicrobial compound is gradually released from the carrier system over time. The surfactant-polymer matrix maintains a reservoir of active compound that continuously releases antimicrobial agents, ensuring both rapid initial action and sustained residual protection, eliminating the gap between application and reapplication
Solution Approach 2:
The carrier system is pre-formulated with the active compound in a controlled-release matrix before application. This preliminary preparation ensures that the active compound is already positioned for immediate action while being structured for sustained release, providing both rapid kill rate and persistent protection without requiring separate fast-acting and long-lasting products
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution achieves prolonged antimicrobial activity, reduces skin irritation, and maintains effective microbial reduction over time, enhancing hand hygiene and infection prevention in healthcare environments.
Implementation Method 1
an ionic moiety attracted to at least one of the binding sites
Implementation Method 2
a hydrophobic moiety attracted to the hydrophobic moiety of the active agent
Implementation Method 3
a dispersed phase within a continuous or aqueous phase
Data Source
AI summary
The present invention relates to the field of carrier and delivery systems for active molecular compounds. In particular, the present invention provides aqueous dispersions for delivery of active molecular compounds.