Arginine and Alpha-Lipoic Acid Composition for Sexual Dysfunction
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Solution Overview
Problem
Current treatments for sexual dysfunction, particularly erectile dysfunction, are limited in addressing the condition comprehensively and often come with severe side effects, and there is a lack of effective therapies for both men and women that can be administered without risk, especially for elderly patients.
Innovation Solution
A composition comprising a nitric oxide donor or precursor, such as arginine, in excess molar amounts combined with α-lipoic acid, a dithiolane, is used to improve sexual function, which can be administered orally in a liquid or solid form, with additional salt partners to enhance solubility and stability, allowing for effective treatment of sexual dysfunctions without severe side effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If current treatments for sexual dysfunction are used, then erectile function may be improved, but severe side effects occur
Solution Approach 1:
The patent combines two substances with different mechanisms of action: an NO donor (such as L-arginine) that increases nitric oxide availability, and a dithiolane (such as α-lipoic acid) that acts as an antioxidant and improves blood flow. This combination therapy achieves improved erectile function while reducing the severe side effects associated with monotherapy using conventional PDE5 inhibitors
Solution Approach 2:
The invention uses a composite formulation comprising multiple active ingredients (NO donor and dithiolane) in specific dosage ranges. This composite approach creates a synergistic effect where the combination of substances provides therapeutic benefits superior to individual components alone, while minimizing adverse effects through the complementary mechanisms of action
2Reliability
If PDE5 inhibitors are used to treat erectile dysfunction, then erection quality improves, but they cannot be used in cardiac or vascular diseases and cause deadly side effects when taken with nitrate medications
Solution Approach 1:
The patent employs an NO donor and dithiolane combination as an intermediary approach that achieves erectile improvement through natural physiological pathways (increasing endogenous nitric oxide and improving blood flow) rather than directly inhibiting PDE5. This intermediary mechanism avoids the dangerous interactions with nitrates and contraindications in cardiac/vascular diseases that characterize PDE5 inhibitor therapy
3Reliability
If a combination of NO donor and dithiolane is used, then sexual function improves without severe side effects, but the composition complexity increases
Solution Approach 1:
The patent optimizes specific parameters including the dosage ranges of each component (NO donor: 1-10g daily, dithiolane: 100-1000mg daily), the molar ratio between components, and administration timing. These parameter optimizations ensure the combination achieves therapeutic effects while maintaining safety, and the complexity is managed through established pharmaceutical formulation practices
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The combination of arginine and α-lipoic acid in specific ratios effectively improves erectile function and overall sexual health in both men and women, including cases of psychogenic dysfunction, without the limitations of existing treatments, and can be used to reduce the dosage of other medications, thereby minimizing adverse interactions.
Implementation Method 1
a substance which improves nitric oxide (NO) availability, re. an NO donor or a precursor of the biosynthesis of nitric oxide
Implementation Method 2
a dithiolane, with α-lipoic acid as a preferred compound
Data Source
AI summary
The present invention relates to solid compositions comprising a substance which improves nitric oxide (NO) availability, re. an NO donor or a precursor of the biosynthesis of nitric oxide or an direct or indirect NO agonist, with arginine being a preferred compound, in combination with a dithiolane, with α-lipoic acid as a preferred compound, and its use for improvement of sexual function. The compositions according to the invention comprise the NO donor or its precursor in excess, based on the molar amount of the constituents. The compositions are also suited for the improvement of sexual function. In particular the present invention relates to the use of a dithiolane in combination with a NO donor or a precursor thereof for the preparation of a medication for treatment of sexual dysfunction.