Arterial Compliance Index Calculation for Real-Time Vascular Assessment
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Solution Overview
Problem
Current methods for measuring arterial compliance and stiffness are technically demanding, costly, and limited in scope, making it difficult to accurately diagnose artery distension, stiffness, blood flow, and resistance in real-time within a routine clinical setting.
Innovation Solution
A non-invasive system and method that combines arterial signature waveform blood flow velocities with systemic blood pressure to calculate an Arterial Compliance Index (ACI), which correlates with blood pressure, artery distension, stiffness, and resistance, allowing for real-time evaluation and comparison to a baseline index.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If current methods for measuring arterial compliance and stiffness are used, then measurement accuracy is improved, but device complexity and cost increase
Solution Approach 1:
The patent combines multiple measurement parameters (blood pressure, peak systolic velocity, end diastolic velocity) into a single integrated Arterial Compliance Index calculation. This merging of measurement approaches allows comprehensive arterial assessment without requiring multiple separate complex devices, thereby maintaining measurement accuracy while reducing overall system complexity and cost.
Solution Approach 2:
The Arterial Compliance Index serves multiple diagnostic functions simultaneously - it assesses arterial compliance, stiffness, blood flow characteristics, and resistance in a single measurement. This multi-functionality eliminates the need for separate specialized equipment for each arterial parameter, resolving the contradiction between comprehensive measurement accuracy and device complexity.
2Measurement precision
If current methods for measuring arterial compliance and stiffness are used, then measurement accuracy is improved, but time consumption increases
Solution Approach 1:
The patent uses routinely collected clinical data (blood pressure readings and Doppler velocity measurements) that are already available from standard cardiovascular assessments. By utilizing these pre-collected parameters, the Arterial Compliance Index calculation requires no additional measurement time while maintaining high diagnostic accuracy for arterial compliance and stiffness.
Solution Approach 2:
The system leverages existing clinical workflows and routinely measured parameters to automatically generate arterial compliance and stiffness assessments. This self-service approach uses data already being collected during standard patient evaluations, eliminating the need for separate time-consuming specialized measurement procedures.
3Adaptability or versatility
If current methods for measuring arterial compliance and stiffness are used, then diagnostic scope is improved, but ease of operation deteriorates
Solution Approach 1:
The patent transforms complex arterial mechanical properties (compliance, stiffness) into a simplified dimensional parameter - the Arterial Compliance Index with units of velocity squared. This parameter transformation maintains comprehensive diagnostic scope for various arterial conditions while making the measurement and interpretation straightforward for clinical use, thereby improving ease of operation.
Data Source
AI summary
A system and method for calculating the arterial compliance, stiffness, and arterial flow and resistance indices for any artery in issue of a subject having a blood pressure monitoring device configured to calculate systolic and diastolic blood pressure readings for an artery of the subject, a blood flow velocity monitoring device configured to calculate the velocity of blood flowing within the artery of the subject at a peak point of a systolic phase of contraction of the subject's heart muscle, peak-systolic velocity, and the velocity of blood flowing within the artery of the subject at an end point of a diastolic phase of the subject's heart muscle, end-diastolic velocity, and a central processing unit comprising a computer readable program embodied within the central processing unit configured to calculate the arterial compliance, stiffness, and arterial flow and resistance indices as a function of the area of the artery under initial systolic and end diastolic pressure, the area of the artery generating arterial elastic recoil pressure for continuous flow during the systolic and diastolic phases, peak-systolic and end-diastolic arterial flow velocities, and systolic and diastolic blood pressure.