Arthrobacter agilis Carotenoid Extract Antioxidant Composition

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Solution Overview

Problem

Current cosmetic and pharmaceutical products face challenges in effectively combating oxidative stress and cellular aging caused by free oxygen radicals and UV radiation, which can lead to damage in skin cells, as existing antioxidant agents may not provide comprehensive protection against these aggressions.

Innovation Solution

A cosmetic and pharmaceutical composition comprising an extract rich in carotenoids from Arthrobacter agilis bacteria, combined with vitamin E or its derivatives, which offers direct protection against free radicals and UV radiation, stabilizing proteins and demonstrating synergistic effects with other antioxidants.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If traditional antioxidant agents are used, then some protection against oxidative stress is provided, but comprehensive protection against free radicals and UV radiation is not achieved

Engineering Contradiction:
Improveprotection efficacyVSAvoidoxidative stress damage
Core Design Contradiction:
ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent combines carotenoid extract from Arthrobacter agilis with vitamin E or its derivatives to create a synergistic antioxidant system. This merging of different antioxidant mechanisms (carotenoid UV absorption and vitamin E free radical scavenging) provides comprehensive protection that neither agent could achieve alone, directly resolving the contradiction between partial and comprehensive protection efficacy

Inventive Principle:
Principle #5Merging (Combining)

Solution Approach 2:

The invention creates a composite antioxidant composition integrating carotenoids (which absorb UV radiation and quench singlet oxygen) with vitamin E (which scavenges free radicals). This composite material approach allows the composition to address multiple harmful factors simultaneously - UV radiation, singlet oxygen, and free radicals - thereby achieving reliable comprehensive protection against oxidative stress

Inventive Principle:
Principle #40Composite materials

2Reliability

If higher concentrations of antioxidants are used, then better protection is achieved, but product complexity and formulation difficulty increase

Engineering Contradiction:
Improveantioxidant protectionVSAvoidformulation complexity
Core Design Contradiction:
ReliabilityVSDevice complexity

Solution Approach 1:

The patent optimizes the concentration ratios and formulation parameters of carotenoid extract and vitamin E to achieve synergistic effects at manageable concentrations. By carefully controlling these parameters, the invention delivers superior antioxidant protection without requiring excessively high concentrations that would complicate the formulation and application

Inventive Principle:
Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition exhibits a strong antioxidant power, significantly protecting proteins and cells against oxidative stress and UV damage, with a protective effect on the proteome that surpasses traditional antioxidants, providing both anti-aging and sun protection benefits.

Implementation Method 1

demonstrating the protection of proteins against reactive oxygen species (ROS) and light radiation (UV and visible) provided by such an extract

Methodology Applied
Scientific EffectLight absorption: Absorption (EM radiation)

Implementation Method 2

exhibiting antioxidant activity of interest... a specific effect of such an extract on damage caused by UV radiation... and more generally, a protective and even stabilizing effect on proteins

Methodology Applied
Scientific EffectAntioxidant activity: Oxidation

Implementation Method 3

This extract, in combination with vitamin E or one of its derivatives used as antioxidants, therefore helps fight oxidative stress

Methodology Applied
Scientific EffectFree radical scavenging: Redox Reactions

Data Source

PatentEP2983797B1Cosmetic, pharmaceutical or food composition comprising carotenoid containing extract of arthrobacter agilis
Publication Date: 2021.03.10 THOREL JEAN NOEL
  • EP2983797B1 patent drawingFigure 1~2
  • EP2983797B1 patent drawingFigure 3~4A
  • EP2983797B1 patent drawingFigure 4B~5

AI summary

The invention relates to a cosmetic, pharmaceutical or food composition including an extract of the Arthrobacter agilis bacterium, advantageously rich in carotenoids.