Artificial Bone Material with Controlled Calcium Ion Elution
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Solution Overview
Problem
Conventional calcium-based artificial bone materials face challenges in preventing cytotoxicity and inflammatory responses due to uncontrolled calcium ion elution, which inhibits cell growth and tissue integration.
Innovation Solution
A method involving surface treatment or impregnation of calcium-based artificial bone materials with chelating agents like gluconic acid or succinic acid to control calcium ion release, reducing elution to 50% or less of the original amount, thereby preventing cytotoxicity and inflammatory responses.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If calcium-based artificial bone materials are used for implantation, then bone filling and tissue integration are achieved, but calcium ion elution causes cytotoxicity and inflammatory responses
Solution Approach 1:
A surface-treating agent is introduced as an intermediary substance between the calcium-based artificial bone material and the surrounding tissue. This agent forms a protective layer on the material surface that mediates the interaction, preventing direct calcium ion release into the tissue while maintaining the material's structural integrity and bone-filled function.
Solution Approach 2:
The surface-treating agent transforms the harmful calcium ion elution into a beneficial controlled release system. By treating the surface, the material's calcium content is converted from a source of cytotoxicity into a controlled therapeutic element that can be released at safe, beneficial rates for bone regeneration.
2Object-affected harmful factors
If surface treatment is applied to suppress calcium ion elution, then cytotoxicity and inflammatory responses are prevented, but additional processing steps are required
Solution Approach 1:
The surface treatment modifies the physical and chemical parameters of the material surface, such as surface charge, porosity, or chemical composition, to control calcium ion release. This parameter modification is achieved through relatively simple treatments like chemical immersion or coating, rather than complex structural changes.
3Reliability
If calcium ion elution is suppressed through surface treatment, then cell growth is promoted, but the treatment process adds manufacturing complexity
Solution Approach 1:
The surface treatment is performed as a preliminary action during the manufacturing process, before implantation. This advance treatment prepares the material with controlled calcium release properties, ensuring that when the material is implanted, the beneficial effect on cell growth is already established without requiring additional complex manufacturing steps later.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The controlled calcium ion elution method effectively suppresses calcium ion release, preventing cytotoxicity and inflammatory responses, and promotes cell growth and tissue integration at the implant site.
Implementation Method 1
impregnating the carrier with a surface-treating agent... the impregnation of the implantable artificial bone material with the surface-treating agent can prevent calcium ion elution from the implantable artificial bone material
Data Source
AI summary
Disclosed is an artificial bone material having controlled calcium ion elution, which does not induce cytotoxicity or any inflammatory response. It is found that the elution of a calcium ion from an artificial bone material for transplantation which contains a calcium-containing substance can be prevented effectively by subjecting the carrier to a surface treatment or adding a surface-treating agent to the carrier. It is also found that the induction of cytotoxicity can be prevented and the induction of an inflammatory response can also be prevented by using the above-mentioned carrier having controlled calcium ion elution.