Artificial Erythrocyte Particles for Urine Sediment Quality Control
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Solution Overview
Problem
The difficulty in obtaining erythrocytes for quality control substances due to ethical concerns and the instability and infectious nature of biological components, which complicates their handling and preservation.
Innovation Solution
The use of artificial particles with forms similar to erythrocytes, made from silicone-based polymers like polymethylsilsesquioxane, that mimic erythrocytes under a microscope, allowing for accurate measurement and analysis in urine sediment analyzers without ethical issues.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If erythrocytes are used as quality control substance, then measurement accuracy for erythrocyte analysis is improved, but ethical problems and handling difficulty arise due to biological component instability and infectious nature
Solution Approach 1:
The patent applies the copying principle by creating artificial particles that replicate the essential visual characteristics of erythrocytes (biconcave disc shape, size range of 6-8 μm, color properties) without using actual biological material. These artificial copies enable quality control testing while completely eliminating ethical concerns and infectious risks associated with using real erythrocytes from human or animal sources.
2Measurement precision
If biological components are used for quality control, then form similarity to actual sediments is improved, but preservation stability deteriorates due to instability of living body components
Solution Approach 1:
The patent applies parameter changes by transforming the material composition from unstable biological components to stable artificial materials (such as polymers or glass) while maintaining critical morphological parameters (shape, size, color) that enable form similarity. This allows the quality control substance to preserve its compositional stability over time while retaining the visual characteristics necessary for accurate sediment analysis.
3Ease of manufacture
If artificial particles are used as quality control substance, then ease of manufacture and preservation stability are improved, but form similarity to erythrocytes may deteriorate
Solution Approach 1:
The patent applies local quality by concentrating the artificial particles' design focus on the specific local characteristics that are most critical for erythrocyte identification under microscopy (biconcave disc shape, 6-8 μm diameter, appropriate coloration) while using readily manufacturable materials. This selective optimization of local features ensures form similarity where it matters most for measurement precision while maintaining ease of manufacture through standardized artificial particle production methods.
Data Source
AI summary
The present disclosure provides a quality control substance for use in the analysis of erythrocytes, which can be prepared safely with easily available raw materials, which has an excellent preservation stability, and which can be used in the analysis of sediments in a sample. This quality control substance includes artificial particles whose form as observed with a microscope is similar to the form of erythrocytes as observed therewith.