Artificial Exosome Complex via Amidation Reaction
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Solution Overview
Problem
Current skin care products lack effective media for delivering active substances to deep skin cells, as linear polyethyleneimine (PEI) and hyaluronic acid (HA) cannot be effectively combined to form a stable microcapsule with cell selectivity, limiting their absorption and persistence.
Innovation Solution
A method to fuse linear PEI and HA through an amidation reaction to create an artificial exosome complex, which forms a microcapsule with controlled molecular weight and structure, enhancing absorption into deep skin cells via ligand activity and membrane permeability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If linear PEI and HA are combined to form a microcapsule, then absorption efficiency and skin care persistence are improved, but the technical difficulty of controlling the amidation reaction and product quality increases
Solution Approach 1:
The patent controls the molecular weight parameters of linear PEI (1,000 to 100,000) and HA (400 to 1,800,000) to optimize the amidation reaction. By adjusting these parameters, the reaction controllability and product quality are improved while maintaining absorption efficiency and skin care persistence.
Solution Approach 2:
The patent creates a composite artificial exosome complex by combining linear PEI and HA through amidation reaction. This composite structure integrates the membrane permeability of PEI with the ligand activity of HA, achieving synergistic effects in skin cell penetration and active substance delivery.
2Reliability
If linear PEI is used to form a microcapsule with membrane fusion property, then delivery capability is improved, but cell selectivity is lost
Solution Approach 1:
The patent modifies the surface properties of the microcapsule by incorporating HA with specific ligand activity. This creates local heterogeneity on the microcapsule surface, enabling selective interaction with specific skin cell receptors while maintaining the overall delivery capability provided by the PEI core.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The artificial exosome complex effectively promotes the absorption of active substances into deep skin layers, offering improved skin care persistence and controlled production suitable for industrial scale.
Implementation Method 1
Linear PEI and HA are both high polymers, rather than small-molecule compounds, so there is an extremely high technical difficulty in the control of such a reaction and a product quality
Implementation Method 2
HA and PEI can play a synergistic role in a skin care product through the ligand activity of HA and the membrane permeability of PEI to facilitate the effective absorption of an active substance into deep skin cells
Data Source
AI summary
A preparation method and use of an artificial exosome complex are provided. Raw materials for preparing the artificial exosome complex include linear polyethyleneimine (PEI) and hyaluronic acid (HA). The linear PEI can be obtained through the HA-PEI preparation process of the present disclosure, and most PEI is branched currently. According to the HA-PEI preparation method, HA-PEI with a specific molecular weight can be quantitatively prepared. The preparation process involves controllable operation steps, and thus can be used for large-scale industrial production. The prepared HA-PEI can promote the absorption of an encapsulated active substance by deep skin cells through the ligand activity of HA and the membrane permeability of linear PEI.