Two-Component ASA Effervescent System for Rapid Dissolution
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Solution Overview
Problem
Current ASA formulations for treating myocardial infarction require water or saliva for dissolution, leading to delayed administration and reduced effectiveness in emergency situations, especially when patients have reduced saliva production or no access to water.
Innovation Solution
A two-component system comprising a first compartment with acetylsalicylic acid (ASA) and a second compartment with an aqueous solution of carbonic acid salt, which quickly mixes to form an aqueous ASA solution upon administration, eliminating the need for additional water or saliva.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If ASA is formulated as effervescent tablets requiring dissolution in water, then ASA can be administered, but administration is delayed by several minutes and requires water or adequate saliva production
Solution Approach 1:
The effervescent tablet is divided into two separate components: Component A containing ASA and citric acid, and Component B containing sodium hydrogen carbonate. This segmentation allows each component to be optimized for its specific function while eliminating the need for prolonged dissolution in water, as the reaction between components generates CO2 bubbles that facilitate rapid dispersal and absorption.
Solution Approach 2:
The acid (citric acid) and base (sodium hydrogen carbonate) components are prepared separately in advance and kept stable in their respective components. Upon contact during administration, they immediately react to produce CO2 effervescence, which rapidly disperses the ASA without requiring dissolution in water or saliva, thus eliminating the time delay associated with traditional effervescent tablets.
2Reliability
If ASA is dissolved in water for administration, then ASA becomes bioavailable, but ASA and its salts hydrolyse rapidly making long-term storage of dissolved ASA impossible
Solution Approach 1:
The formulation separates ASA from water into Component A (ASA with citric acid in dry or minimal moisture environment) and Component B (aqueous sodium hydrogen carbonate solution). This segmentation allows Component A to be stored stably without hydrolysis, while Component B provides the aqueous environment needed for bioavailability only at the moment of administration when the components are mixed.
Solution Approach 2:
Citric acid serves as an intermediary that facilitates the reaction between ASA and sodium hydrogen carbonate. When Component A and Component B are mixed, citric acid reacts with sodium hydrogen carbonate to produce CO2 effervescence, which simultaneously disperses ASA into the aqueous phase for rapid absorption, achieving bioavailability without requiring pre-dissolution and storage of ASA in water.
3Reliability
If traditional effervescent tablets are used, then ASA can be administered, but the tablets must be dissolved in water or saliva which may not be available in emergency situations
Solution Approach 1:
The formulation divides the effervescent system into two components that can be administered together without requiring external water. Component A contains ASA and citric acid (dry or with minimal moisture), while Component B contains sodium hydrogen carbonate in aqueous solution. The internal water in Component B suffices for the reaction, making the formulation independent of external water availability while maintaining effervescent dispersal and ASA bioavailability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This solution enables rapid and effective administration of ASA, reducing the risk of myocardial infarction damage and improving patient survival by providing a ready-to-use ASA solution within minutes, independent of water or saliva availability.
Implementation Method 1
the second component comprises an aqueous solution comprising a salt of carbonic acid... enables an immediate dissolution of ASA upon mixing of the first and second components
Data Source
AI summary
The present invention relates to a novel two-component system comprising acetylsalicylic acid (ASA) and which is particularly useful in providing an aqueous solution of ASA for immediate peroral administration.