Bowel Cleansing Composition Using Ascorbate to Reduce Volume
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Solution Overview
Problem
Current bowel cleansing agents, particularly those containing polyethylene glycol, face challenges such as high volume requirements, unpleasant taste, and significant side effects like nausea and vomiting, leading to low patient compliance and potential safety issues during colonoscopy preparations.
Innovation Solution
A bowel cleansing composition comprising polyethylene glycol (PEG) and ascorbate ingredients, with specific molecular weight ranges and ratios, is developed to reduce the dose while maintaining effective bowel cleansing, improving taste, and minimizing side effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a large volume of polyethylene glycol-based bowel cleansing agent is taken to achieve effective bowel cleansing, then the bowel cleansing effect is improved, but the side effects such as nausea and vomiting increase and patient compliance decreases
Solution Approach 1:
The patent changes the chemical composition parameters by introducing ascorbate ingredients (ascorbic acid and/or ascorbate salts) in specific amounts (5-50 g per liter of preparation) to modify the properties of the bowel cleansing agent. This parameter change allows reduction of the overall volume required while maintaining cleansing efficacy and reducing side effects through the ascorbate's protective and taste-improving effects
Solution Approach 2:
The patent creates a composite bowel cleansing preparation by combining polyethylene glycol (the traditional active ingredient) with ascorbate ingredients (ascorbic acid and/or ascorbate salts). This composite formulation leverages the synergistic effects of both components: polyethylene glycol provides the primary bowel cleansing action while ascorbate reduces side effects and improves palatability, allowing effective cleansing with reduced volume
2Ease of operation
If the volume of bowel cleansing agent is reduced to improve patient compliance and reduce side effects, then the convenience of taking is improved, but the bowel cleansing effect may be compromised
Solution Approach 1:
The patent modifies the concentration parameters by formulating a higher concentration of active ingredients (polyethylene glycol and ascorbate) in a reduced volume. The specific formulation contains 20-40 g/L polyethylene glycol and 5-50 g/L ascorbate ingredients, creating a potent concentrated preparation that achieves effective cleansing with only 500 mL to 2 L volume, significantly less than traditional formulations
Solution Approach 2:
The composite formulation of polyethylene glycol combined with ascorbate ingredients creates a synergistic effect where the ascorbate enhances the overall efficacy per unit volume. This allows the preparation to be more concentrated and potent, delivering effective bowel cleansing in a smaller, more manageable volume that improves patient compliance
3Ease of operation
If the taste of the bowel cleansing agent is improved to increase patient compliance, then the ease of operation is improved, but the formulation complexity increases
Solution Approach 1:
The patent changes the formulation parameters by incorporating ascorbate ingredients (ascorbic acid and/or ascorbate salts) at concentrations of 5-50 g per liter. These ingredients naturally improve taste and palatability while also providing physiological benefits. The formulation may additionally include sweeteners and flavoring agents, creating a multi-component formulation that addresses taste concerns without excessive complexity
Data Source
AI summary
The present invention relates to a bowel cleansing composition comprising polyethylene glycol and ascorbate ingredients, the bowel cleansing composition of the present invention being easier to take, while having an excellent bowel cleansing effect, thereby being usable as an effective bowel cleansing agent.