Ascorbate-Modified Polysaccharide Fillers for Faster Resorption
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Solution Overview
Problem
Polysaccharides used as cosmetic fillers and drug delivery systems have a prolonged resorption time in the body, leading to issues like discomfort, graininess, nodules, and difficulty in redistribution.
Innovation Solution
Administering ascorbate, such as ascorbic acid, to polysaccharides before or after placement in the body alters their physical and chemical properties, making them more fluid and facilitating faster resorption and smoother integration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of stationary object
If polysaccharides are used as cosmetic fillers and drug delivery systems, then they provide filler mass and drug delivery capability, but they have long resorption times and potential discomfort during administration
Solution Approach 1:
The patent applies parameter changes by modifying the chemical structure of polysaccharides through oxidation (changing molecular weight, degree of oxidation, and other parameters) to create oxidized polysaccharides with improved resorption characteristics and reduced adverse effects while maintaining filler and drug delivery functions
Solution Approach 2:
The patent creates composite materials by combining oxidized polysaccharides with other substances such as hyaluronic acid, anesthetic agents, and drugs to form compositions that simultaneously achieve faster resorption, reduced discomfort, and enhanced therapeutic effects
2Quantity of substance
If polysaccharide fillers are administered in deep skin layers, then they provide filler mass, but they may cause hardness, graininess, and skin marking
Solution Approach 1:
The patent modifies the physical and chemical parameters of polysaccharides through oxidation to alter their rheological properties, making them softer and more uniform in distribution, thereby reducing hardness, graininess, and skin marking while maintaining adequate filler mass
Solution Approach 2:
The patent applies local quality by ensuring uniform distribution and appropriate concentration of oxidized polysaccharides in specific skin layers, preventing localized areas of excessive density that would cause hardness and graininess
3Speed
If polysaccharides are modified to improve resorption and fluidity, then resorption speed and fluidity increase, but the structural integrity and stability may be compromised
Solution Approach 1:
The patent carefully controls the degree of oxidation and molecular weight parameters to achieve an optimal balance where resorption speed is enhanced through increased water solubility and metabolic recognition, while sufficient structural integrity is maintained to provide adequate filler support and drug delivery capability
Solution Approach 2:
The patent applies partial action by performing controlled oxidation to a specific degree rather than complete degradation, achieving sufficient resorption enhancement while preserving the necessary structural framework for filler and drug delivery functions
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The use of ascorbate fluidizes polysaccharides, improving their feel and reducing graininess, nodules, and enabling easier redistribution and resorption, enhancing the cosmetic and therapeutic efficacy of dermal fillers and drug delivery systems.
Implementation Method 1
Ascorbate alters the form of the polysaccharide, increasing its dissolution, breaking down and fluidizing the mass
Data Source
AI summary
Embodiments of the present invention are directed to kits, compositions and methods for modifying and altering polysaccharide fillers and drug delivery systems with the application of an ascorbate.