Ascorbic Acid Polymer Mesh for Tissue Regeneration
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Solution Overview
Problem
Current implantable medical devices for tissue regeneration, such as those used in hernia repair, face challenges in integrating therapeutic agents like ascorbic acid effectively while maintaining the integrity of the film/mesh attachment, especially in accommodating unique patient/anatomical features.
Innovation Solution
A method is developed to form biodegradable polymer compositions by contacting ascorbic acid with a diacid to produce an ester acid, converting it to an isocyanate, and then polymerizing it with aminoalcohols, polyamines, or polyols to create polyurethanes or polyureas, which are applied to a substrate, such as a mesh, for sustained release of ascorbic acid during tissue regeneration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If therapeutic agents like ascorbic acid are integrated into implantable medical devices for tissue regeneration, then tissue regeneration is enhanced, but the integrity of film/mesh attachment may be compromised
Solution Approach 1:
The patent combines the therapeutic agent (ascorbic acid) with the mesh structure by integrating it into the polymer composition that forms the mesh itself, rather than as a separate film layer. This merging ensures the therapeutic agent is delivered sustainably while maintaining the structural integrity of the mesh attachment to tissue.
Solution Approach 2:
The patent uses a composite polymer composition comprising polyglycolic acid and ascorbic acid in specific ratios (0.1-10% by weight). This composite material approach allows the therapeutic benefits of ascorbic acid to be incorporated while maintaining the mechanical properties and attachment integrity of the polyglycolic acid mesh structure.
2Duration of action of moving object
If films are added to meshes for sustained delivery of therapeutic agents, then therapeutic delivery is improved, but integration complexity increases
Solution Approach 1:
Instead of adding a separate film layer to the mesh, the patent merges the therapeutic delivery function directly into the mesh structure by incorporating ascorbic acid into the polymer composition. This eliminates the need for separate film integration while achieving sustained therapeutic delivery through the degradation of the polyglycolic acid mesh.
Solution Approach 2:
The polyglycolic acid mesh serves multiple functions simultaneously: it provides the structural framework for tissue regeneration, acts as the delivery vehicle for ascorbic acid, and maintains attachment integrity. This multi-functionality eliminates the need for separate specialized film components.
3Duration of action of moving object
If polymeric compositions with ascorbic acid are used, then sustained release of ascorbic acid is achieved, but manufacturing complexity increases
Solution Approach 1:
The ascorbic acid is pre-mixed with the polyglycolic acid polymer in specific ratios before forming the mesh structure. This preliminary incorporation ensures uniform distribution of the therapeutic agent throughout the mesh, enabling sustained release as the mesh degrades, while simplifying manufacturing compared to post-formation impregnation methods.
Solution Approach 2:
The patent optimizes the concentration of ascorbic acid in the polymer composition (0.1-10% by weight) to achieve the desired sustained release profile. By adjusting this parameter, the manufacturing process can be tuned to produce meshes with different release characteristics without fundamentally changing the fabrication approach.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enhances collagen formation and tissue regeneration by providing a biodegradable polymer composition that promotes sustained release of ascorbic acid, improving the integration of therapeutic agents and maintaining the integrity of the film/mesh attachment, thus addressing the integration challenges in existing devices.
Implementation Method 1
contacting ascorbic acid with a diacid to produce an ester acid; converting the ester acid to an isocyanate
Implementation Method 2
contacting the isocyanate with a monomer selected from the group consisting of a polyol, a polyamine, an aminoalcohol, and combinations thereof to form a polymer selected from the group consisting of polyurethanes, polyureas, and combinations thereof
Implementation Method 3
biodegradable polymer composition that promotes sustained release of ascorbic acid during tissue regeneration
Data Source
Figure 1A~1C
AI summary
An implantable medical device is disclosed. The medical device includes a substrate and a polymer composition including ascorbic acid, the polymer composition disposed on at least a portion of the substrate.