Aseptic Layered Dissection for Mixed Microbe Infection Mapping
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Solution Overview
Problem
Current treatments for mixed microbe infections in dental and other lesions are inadequate, often leading to recurrence and failure of implants due to untreated microbial infections, as they do not effectively characterize and remove the underlying microbial causes.
Innovation Solution
A method for aseptic dissection and characterization of mixed microbial infections, involving sequential layer-by-layer removal and identification of microorganisms in lesions, followed by disinfection and sealing to prevent further infection.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional treatments are used for mixed microbe infections, then treatment simplicity is maintained, but infection recurrence and implant failure increase due to inadequate microbial characterization and removal
Solution Approach 1:
The lesion is divided into multiple layers through sequential dissection, with each layer being individually characterized for microbial composition. This segmentation allows identification of the advancing front of infection and differential treatment of various microbial populations within the lesion structure.
Solution Approach 2:
Different regions of the lesion are treated differently based on their microbial composition and depth. The advancing front is identified and targeted specifically, while other areas receive appropriate treatment. This local differentiation improves treatment effectiveness by addressing the specific microbial challenges in each lesion region.
2Measurement precision
If complete microbial characterization is performed, then treatment precision improves, but time required for analysis and dissection increases
Solution Approach 1:
The dissection and microbial characterization process is performed preliminarily during the treatment procedure itself, allowing real-time identification of the advancing front of infection. This preliminary action enables immediate treatment adjustment without requiring separate post-treatment analysis time.
Solution Approach 2:
The dissection, microbial characterization, and treatment adjustment occur in continuous sequence without interruption. The useful action of identifying and treating the advancing front is maintained throughout the procedure, eliminating idle time between analysis and treatment modification.
3Reliability
If aseptic dissection is performed to remove microorganisms, then infection removal effectiveness improves, but risk of contamination and procedural complexity increases
Solution Approach 1:
An aseptic environment is created during the dissection procedure, effectively isolating the lesion from external contamination sources. This inert environment allows thorough microbial removal while preventing introduction of new contaminants, thereby improving reliability without increasing harmful factors.
4Measurement precision
If sequential layer-by-layer removal is performed, then identification of advancing front improves, but tissue damage and procedural complexity increase
Solution Approach 1:
The lesion is segmented into layers to systematically identify the advancing front of infection. This segmentation allows precise localization of the most active microbial regions while enabling selective removal that minimizes unnecessary tissue damage compared to conventional single-stage treatments.
Data Source
AI summary
A system and method for novel processes of isolation, aseptic collection, genus-specie identification and quantification, and mapping of a restricted mixed microbe infection in living tissues in situ showing spatial distribution of the microbes within a sample of the living tissue. A tooth lesion or extraction socket and an endodontic entry excavation adjacent to an implant are examples of lesions resulting from such mixed microbe infections. The process may be incorporated into treatment procedures in a restricted area within hard or soft tissue, diagnostic techniques, minimizing failure of treatment processes, and validation of methods and products claiming antimicrobial or other properties in a treatment or preventive technique.